TLDR Thyroid hormones are important for skin health and might help treat skin diseases, but more research is needed to understand their effects fully.
The 2012 document reviews the role of thyroid hormone in skin physiology and its potential as a treatment for skin diseases. It discusses the historical skin symptoms associated with thyroid disorders, the presence of thyroid hormone receptors in skin cells, and the conversion of T4 to T3 in the skin. The review also examines the effects of thyroid hormone on skin cell proliferation, epidermal and dermal changes, hair and nail growth, and autoimmune skin manifestations related to thyroid dysfunction. While in vitro studies show thyroid hormone stimulates skin cell proliferation, the in vivo effects are still debated. The document also reports that topical thyroid hormone and analogs can promote skin and hair growth in animals, and that high doses of T3 can speed up wound healing in rodents, with a potential formulation for human wound healing including T4. However, the impact on human wound healing is unclear, with mixed study results. The conclusion suggests that thyroid hormone pathways are significant for skin health and could be targeted for treating skin diseases, but more research is needed to fully understand the effects.
49 citations,
December 2009 in “Journal of Investigative Dermatology” Thyroid function affects skin health, with a complex interaction between the two.
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12 citations,
January 2003 in “Dermatology Online Journal” A new treatment for hair loss was tested and most participants saw their hair loss stop within 2-8 weeks, with up to 50% more hair after 4 months, and no side effects.
155 citations,
December 2002 in “Journal of Investigative Dermatology” Thyroid-related genes are active in skin cells and may affect autoimmune conditions.
111 citations,
April 2000 in “British journal of dermatology/British journal of dermatology, Supplement” Thyroid hormone receptor β1 is found in human hair follicles and helps them survive.
32 citations,
March 2021 in “Journal of endocrinological investigation” Thyroid hormones are important for skin health and changes in them can affect conditions like hair loss and eczema.
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66 citations,
July 2015 in “Journal of Molecular Biology” The document concludes that for hair and feather growth, it's better to target the environment around stem cells than the cells themselves.
January 2008 in “Springer eBooks” Thyroid hormone may be useful for treating various skin conditions and needs more research.
1 citations,
April 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” Goat skin changes with the seasons due to genes affected by daylight and hormones.
146 citations,
January 2004 in “Hormones” Human skin acts like a hormone-producing organ, making and managing various hormones important for skin and hair health.
