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Glossary Autoimmune Diseases

immune system attacks the body's own tissues

Autoimmune diseases are conditions where the immune system mistakenly attacks the body's own tissues, thinking they are foreign invaders. This can lead to a variety of health issues, depending on which part of the body is targeted. Examples include rheumatoid arthritis, where joints are affected, and alopecia areata, where hair follicles are attacked, leading to hair loss.

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Research

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research Increased Circulating CXCL10 in Non-Segmental Vitiligo Concomitant with Autoimmune Thyroid Disease and Alopecia Areata

17 citations , January 2019 in “Annals of Dermatology”

This study found that higher serum CXCL10 levels may predict the progression of non-segmental vitiligo, especially in patients also suffering from autoimmune thyroid disease and/or alopecia areata.

research Immune-Molecular Link between Thyroid and Skin Autoimmune Diseases: A Narrative Review

6 citations , September 2024 in “Journal of Clinical Medicine”

This review explored the relationship between autoimmune thyroiditis and various autoimmune skin conditions, highlighting shared genetic markers and immunological mechanisms, such as disrupted immune tolerance and oxidative stress, which may contribute to the development of these disorders.

research Autoimmune thyroid disease and human health: a systematic review of Mendelian randomization studies

4 citations , December 2025 in “Frontiers in Immunology”

This systematic review of Mendelian randomization studies reports that autoimmune thyroid disease is associated with increased risk for numerous health conditions, including coronary atherosclerosis and rheumatoid arthritis, while decreasing risks for others, such as lung cancer.

research Risk of autoimmune thyroid diseases in individuals with alopecia areata: A nationwide case‐control study

1 citations , August 2025 in “JDDG Journal der Deutschen Dermatologischen Gesellschaft”

This population-based study found a significant association between alopecia areata and autoimmune thyroid diseases, including Hashimoto's and Graves' disease, confirming a higher prevalence of these conditions in individuals with alopecia areata.

research JAK1 gain-of-function variant causes alopecia areata, atopic dermatitis, and autoimmune thyroid disease

1 citations , October 2025 in “Journal of Allergy and Clinical Immunology”

A JAK1 variant causes hair loss, skin issues, and thyroid disease, but treatment with a specific inhibitor can help.

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Community Join

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community Diffuse Thinning From Low Iron and Thyroid -Finally Seeing Regrowth After Fixing the Root Cause

26 upvotes 11 months ago

A female experienced hair loss due to low iron and an undiagnosed thyroid issue, specifically Hashimoto's, and saw improvement after starting thyroid medication, iron supplements, and making lifestyle changes. She emphasizes the importance of addressing the root cause and shares her journey to regrowth and emotional recovery.

community Calling out diffuse thinners here -- Have you ruled out other factors?

in Treatment 54 upvotes 1 year ago

Diffuse hair loss is often linked to genetics but can also be due to health issues like thyroid problems and low vitamin or iron levels. Treatments include finasteride, minoxidil, and dutasteride, with some seeing improvements after addressing health issues.

community Not everyone should immediately go on Fin if they are starting to bald

in Finasteride/Dutasteride 21 upvotes 2 years ago

The conversation suggests that people should consult a dermatologist to understand their type of hair loss before starting treatments like finasteride or dutasteride, especially if they have autoimmune issues or low DHT. Some participants believe in starting treatment like finasteride immediately if hair loss is due to DHT, while others recommend ruling out other causes and considering minoxidil first, especially for younger individuals.

community fin 0.5 mg everday 6 months update

in Finasteride/Dutasteride 28 upvotes 2 years ago

The post discusses the experiences of individuals with diffuse hair thinning using finasteride, with many reporting no improvement or worsening conditions after 6 months. Various suggestions include persisting with the treatment, checking for underlying conditions, adding minoxidil for volume, adjusting dosage, and considering other potential causes like autoimmune responses and inflammation.

community Can I take bicalutamide for hair loss as a man, but don’t want to transition?

in Treatment 4 upvotes 6 months ago

A 23-year-old man with hair loss, despite using dutasteride, oral minoxidil, and RU58841, is considering bicalutamide for regrowth but is concerned about feminization. Alternatives like topical estrogen, JXL069, and spironolactone are discussed, with suggestions to explore thyroid levels and other potential underlying conditions.

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Clinics

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Hair Transplant
Wellness Medical Clinic & Thyroid Treatment CenterDiamond Bar, CA · US

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