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Glossary Autoimmune Factors

immune system mistakenly attacks body's own tissues

Autoimmune factors refer to elements within the body that mistakenly target and attack its own tissues, thinking they are foreign invaders. This can lead to various autoimmune diseases, such as alopecia areata, where the immune system attacks hair follicles, resulting in hair loss.

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Research

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research Risk factors for the development of and outcomes after diagnosis of autoimmune alopecia areata in patients with inflammatory bowel diseases

April 2024 in “Research Square”

IBD patients treated with TNF antagonists may develop autoimmune alopecia areata, with severe cases less likely to improve.

research Prevalence and Risk Factors Associated with the Occurrence of Autoimmune Diseases in Patients with Alopecia Areata

14 citations , September 2021 in “Journal of Inflammation Research”

This study suggests that female patients with alopecia areata, especially those with nail abnormalities and atopic diseases, may have higher rates of coexisting autoimmune diseases.

research Prevalence and Risk Factors Associated with the Occurrence of Autoimmune Diseases in Patients with Alopecia Areata

1 citations , September 2021 in “DOAJ (DOAJ: Directory of Open Access Journals)”

This study suggests that female patients with alopecia areata, especially those with nail abnormalities and atopic diseases, have a higher prevalence of autoimmune disease comorbidities.

research The role of B cell-activating factor system in autoimmune diseases: mechanisms, disease implications, and therapeutic advances

4 citations , June 2025 in “Frontiers in Immunology”

This review discusses the role of the BAFF system in autoimmune diseases and highlights its therapeutic potential, emphasizing the need for disease-specific clinical trials to improve treatment strategies.

research Cardiometabolic Risk Factors in Atorvastatin-Treated Women with Euthyroid Autoimmune Thyroiditis

4 citations , January 2023 in “Pharmacology”

This study found that euthyroid women with Hashimoto’s thyroiditis experienced less benefit from atorvastatin treatment in terms of cardiometabolic marker improvements compared to women with hypercholesterolemia but without thyroid issues, indicating a differential response in these populations.

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Community Join

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community Calling out diffuse thinners here -- Have you ruled out other factors?

in Treatment 54 upvotes 1 year ago

Diffuse hair loss is often linked to genetics but can also be due to health issues like thyroid problems and low vitamin or iron levels. Treatments include finasteride, minoxidil, and dutasteride, with some seeing improvements after addressing health issues.

community Diet changes w Alopecia areata.

5 upvotes 1 week ago

The conversation discusses alopecia areata and whether diet changes can resolve it. One user mentions that their condition fluctuates without dietary changes, suggesting stress as a possible factor.

community Started OM and Fin one year ago

in Female 5 upvotes 4 months ago

The user is experiencing significant hair shedding despite using 1.25mg oral minoxidil and 1mg finasteride daily for a year. They are advised to monitor health factors like vitamin levels and heart health, and consider increasing ferritin levels for optimal hair growth.

community Bloodflow? Does it affect hair growth?

23 upvotes 7 years ago

Hair loss is primarily caused by genetic sensitivity to DHT, not lifestyle factors like diet or exercise. Treatments like Minoxidil and Finasteride can help, but it's important to consult a dermatologist to determine the best approach for individual cases.

community Alcohol consumption triggering sheds.

4 upvotes 4 years ago

Alcohol consumption can trigger hair shedding and affect hair treatment effectiveness, especially in those with autoimmune diseases. Treatments mentioned include RU58841, oral minoxidil, and stemoxydine, with finasteride also noted by another user.

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Learn

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learn Alopecia Areata

autoimmune disorder causing patchy hair loss

learn Microneedling

Technique that makes tiny punctures in the scalp with fine needles

learn Neem Oil

Oil from the neem tree, used in traditional remedies

learn Cetirizine

Could cetirizine help control autoimmune triggers in alopecia areata? No published trial has tested cetirizine in alopecia areata; one registered trial has not reported results. Small trials in pattern hair loss report modest benefit, so any use for alopecia areata is off-label and unproven.

learn Tofacitinib

What is tofacitinib, and why is it discussed in relation to autoimmune-related hair loss such as alopecia areata? Tofacitinib is a prescription JAK inhibitor approved for rheumatoid arthritis, psoriatic arthritis and ulcerative colitis — not for alopecia areata. It is discussed for hair loss because a 2014 case report and a 2016 open-label trial reported regrowth in severe alopecia areata, but that use is off-label, the regrowth relapsed after stopping, and the drug carries an FDA boxed warning.

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