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GlossaryLesional Skin

areas of skin showing visible abnormalities or damage

Lesional skin refers to areas of the skin that exhibit visible abnormalities or damage, such as rashes, sores, or other disruptions in normal skin structure. These lesions can result from various conditions, including infections, autoimmune diseases, or physical trauma, and are often the focus of medical examination and treatment.

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Alopecia Areata Patients Show Deficiency of FOXP3+CD39+ T Regulatory Cells and Clonotypic Restriction of Treg TCRβ-Chain, Highlighting the Immunopathological Aspect of the Disease

research Alopecia Areata Patients Show Deficiency of FOXP3+CD39+ T Regulatory Cells and Clonotypic Restriction of Treg TCRβ-Chain, Highlighting the Immunopathological Aspect of the Disease

30 citations , July 2019 in “PloS one”

Patients with Alopecia areata have fewer specific immune cells that normally regulate the immune system, which may contribute to the condition.

research Body Site Heterogeneity and Microbial Diversity Is Lost in Individuals with Hidradenitis Suppurativa

1 citations , April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

People with Hidradenitis Suppurativa have less diverse skin bacteria and different bacterial metabolism than healthy individuals.

research Aberrant Inflammasome Activation as a Driving Force of Human Autoimmune Skin Disease

3 citations , May 2023 in “Frontiers in immunology”

Faulty inflammasome activation may lead to autoimmune skin diseases and could be a target for new treatments.

research MTORC1 Activity Is Increased in the Skin of Acne Patients and Is Suppressed With Isotretinoin Treatment

April 2023 in “Journal of Investigative Dermatology”

Acne patients have higher skin mTORC1 activity, which is reduced by isotretinoin treatment.

research High Throughput T Cell Receptor Sequencing Identifies Clonally Expanded CD8+ T Cell Populations in Alopecia Areata

1 citations , November 2018 in “immuneACCESS”

Expanded CD8+ T cells are linked to Alopecia Areata and may cause relapse after treatment.

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