The Potential Application of Natural Products in Cutaneous Wound Healing: A Review of Preclinical Evidence

This review highlighted the potential of natural products (NPs) in treating nonhealing wounds by examining their mechanisms and targets. It was found that NPs influenced several signaling pathways, including PI3K-AKT, P38MAPK, MAPK, and ERK, and involved factors like tumor growth factor, vascular endothelial growth factor, TNF-α, and interleukin-1β. The study systematically summarized 25 NPs across six major compound classes—saponins, polyphenols, flavonoids, anthraquinones, polysaccharides, and others—emphasizing their role in wound healing and suggesting directions for future research and development of new wound healing products.