Green Fabrication of Seedbed-Like Flammulina Velutipes Polysaccharides-Derived Scaffolds Accelerating Full-Thickness Skin Wound Healing Accompanied by Hair Follicle Regeneration

November 2020 in “ International Journal of Biological Macromolecules ”

Feixiang Chen, Qiang Zhang, Ping Wu, Yanan Zhao, Xiaotong Suo, Ao Xiao, Meifang Ke, Xiaohua He, Zan Tong, Yun Chen

Flammulina velutipes polysaccharides scaffolds skin wound healing hair follicle regeneration FPS/NaOH microenvironment responsive cells mushroom polysaccharides wound healing hair regrowth

TLDR Mushroom-based scaffolds help heal skin wounds and regrow hair.

The study investigated the use of Flammulina velutipes polysaccharides-derived scaffolds (FPDSS) for skin wound healing and hair follicle regeneration. The results showed that FPDSS could provide a favorable microenvironment for skin tissue regeneration and hair follicle regeneration. Among the FPDSS groups, the FPS/NaOH group had the best wound-healing capacity and maximum number of responsive cells in the microenvironment. The study suggests that FPDSS, especially FPS/NaOH, can promote wound healing and hair follicle regeneration.

View this study on sciencedirect.com →

Discuss this study in the Community →

Research cited in this study

6 / 6 results

research Crafting Polymeric and Peptidic Hydrogels for Improved Wound Healing

68 citations, March 2019 in “Advanced Healthcare Materials”

Advanced hydrogel systems with therapeutic agents could greatly improve acute and chronic wound treatment.

research Tissue Engineering of Human Hair Follicles Using a Biomimetic Developmental Approach

184 citations, December 2018 in “Nature Communications”

Researchers created human hair follicles using a new method that could help treat hair loss.

research The Immunology of the Porcine Skin and Its Value as a Model for Human Skin

353 citations, July 2015 in “Molecular immunology”

Porcine skin is very similar to human skin, making it a useful model for research.

research Wound Healing and Skin Regeneration

359 citations, January 2015 in “Cold Spring Harbor Perspectives in Medicine”

Hair growth phase and certain genes can speed up wound healing, while an inflammatory mediator can slow down new hair growth after a wound. Understanding these factors can improve tissue regeneration during wound healing.

research Epithelial Stem Cells And Implications For Wound Repair

156 citations, October 2012 in “Seminars in Cell & Developmental Biology”

Different types of stem cells in hair follicles play unique roles in wound healing and hair growth, with some stem cells not originating from existing hair follicles but from non-hair follicle cells. WNT signaling and the Lhx2 factor are key in creating new hair follicles.

research An Extended Epidermal Response Heals Cutaneous Wounds in the Absence of a Hair Follicle Stem Cell Contribution

170 citations, November 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

Skin can heal wounds without hair follicle stem cells, but it takes a bit longer.

Related Research

9 / 9 results

research Diverse Cellular Players Orchestrate Regeneration After Wounding

7 citations, November 2020 in “Experimental Dermatology”

Different cell types work together to repair skin, and targeting them may improve healing and reduce scarring.

Green Fabrication of Seedbed-Like Flammulina Velutipes Polysaccharides-Derived Scaffolds Accelerating Full-Thickness Skin Wound Healing Accompanied by Hair Follicle Regeneration

research Green Fabrication of Seedbed-Like Flammulina Velutipes Polysaccharides-Derived Scaffolds Accelerating Full-Thickness Skin Wound Healing Accompanied by Hair Follicle Regeneration

14 citations, November 2020 in “International Journal of Biological Macromolecules”

Mushroom-based scaffolds help heal skin wounds and regrow hair.

Injectable Silver Nanoclusters-Based Hydrogel for Wound Healing by Eliminating Bacterial Infection and Promoting Tissue Regeneration

research Injectable Silver Nanoclusters-Based Hydrogel for Wound Healing by Eliminating Bacterial Infection and Promoting Tissue Regeneration

21 citations, November 2020 in “Chemical Engineering Journal”

The hydrogel with silver and mangiferin helps heal wounds by killing bacteria and aiding skin and tissue repair.

research Hedgehog Stimulates Hair Follicle Neogenesis by Creating Inductive Dermis During Murine Skin Wound Healing

145 citations, November 2018 in “Nature Communications”

The Sonic hedgehog pathway is crucial for new hair growth during mouse skin healing.

research Understanding the Functional Contribution of Dermal Stem Cells to Hair Follicle Regeneration and Skin Wound Healing

January 2017

Dermal stem cells help regenerate hair follicles and heal skin wounds.

research Wound Healing and Skin Regeneration

359 citations, January 2015 in “Cold Spring Harbor Perspectives in Medicine”

research Sept4/ARTS Regulates Stem Cell Apoptosis and Skin Regeneration

78 citations, June 2013 in “Science”

Mice without the Sept4/ARTS gene heal wounds better due to more stem cells that don't die easily.

Transplantation of Bone-Marrow-Derived Mesenchymal and Epidermal Stem Cells Contribute to Wound Healing with Different Regenerative Features

research Transplantation of Bone-Marrow-Derived Mesenchymal and Epidermal Stem Cells Contribute to Wound Healing with Different Regenerative Features

36 citations, April 2013 in “Cell and Tissue Research”

Bone-marrow and epidermal stem cells help heal wounds differently, with bone-marrow cells aiding in blood vessel formation and epidermal cells in hair growth.

research The Influence of Flightless I: Regeneration Versus Wound Healing

1 citations, March 2011 in “Journal of Investigative Dermatology”

Blocking RANK signaling might help treat metastatic melanoma, but more research is needed.