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    Glossary Keratinization

    process where skin cells produce keratin and become tough

    Keratinization, also known as cornification, is the biological process by which keratin, a protective protein, is produced and accumulated in cells of the epidermis, the outermost layer of the skin. This process results in the formation of a tough, protective layer of dead cells that helps to prevent water loss and protect against environmental damage, pathogens, and physical abrasion.

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    1. Keratinization and its Disorders Oman Medical Journal · 2012 · 95 citations
    2. Increased expression of keratin 16 causes anomalies in cytoarchitecture and keratinization in transgenic mouse skin. The Journal of Cell Biology · 1994 · 94 citations
    3. Patterns of epithelial expression of Fos protein suggest important role in the transition from viable to cornified cell during keratinization Development · 1991 · 83 citations
    4. Structural and Immunocytochemical Characterization of Keratinization in Vertebrate Epidermis and Epidermal Derivatives International review of cytology · 2006 · 82 citations
    5. The Process of Cornification Evolved From the Initial Keratinization in the Epidermis and Epidermal Derivatives of Vertebrates: A New Synthesis and the Case of Sauropsids International review of cell and molecular biology · 2016 · 73 citations
    6. Outer root sheath keratinization in anagen and catagen of the mammalian hair follicle. A seventh distinct type of keratinization in the hair follicle: trichilemmal keratinization. PubMed · 1981 · 59 citations
    7. Embryonic keratinization in vertebrates in relation to land colonization Acta Zoologica · 2008 · 44 citations
    8. Disorders of Keratinization American journal of clinical dermatology · 2004 · 44 citations
    9. Hidradenitis Suppurativa as a Potential Subtype of Autoinflammatory Keratinization Disease Frontiers in immunology · 2020 · 41 citations
    10. Retinoids and Keratinization International Journal of Dermatology · 1988 · 32 citations
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