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GlossaryKeratinization

process where skin cells produce keratin and become tough

Keratinization, also known as cornification, is the biological process by which keratin, a protective protein, is produced and accumulated in cells of the epidermis, the outermost layer of the skin. This process results in the formation of a tough, protective layer of dead cells that helps to prevent water loss and protect against environmental damage, pathogens, and physical abrasion.

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research Structural and Immunocytochemical Characterization of Keratinization in Vertebrate Epidermis and Epidermal Derivatives

82 citations , January 2006 in “International review of cytology”

Vertebrate skin evolved to be more specialized and complex, especially in land animals.

research The Process of Cornification Evolved From the Initial Keratinization in the Epidermis and Epidermal Derivatives of Vertebrates: A New Synthesis and the Case of Sauropsids

73 citations , January 2016 in “International review of cell and molecular biology”

Cornification evolved from keratinization in vertebrates, with differences between mammals and sauropsids.

research Disorders of Keratinization

44 citations , January 2004 in “American journal of clinical dermatology”

Understanding genetic mutations helps diagnose and treat skin disorders like ichthyosis.

research Embryonic Keratinization in Vertebrates in Relation to Land Colonization

44 citations , May 2008 in “Acta Zoologica”

Keratinization in embryos helped vertebrates adapt to land by forming a protective skin barrier.

research Hidradenitis Suppurativa as a Potential Subtype of Autoinflammatory Keratinization Disease

41 citations , May 2020 in “Frontiers in immunology”

Hidradenitis suppurativa might be a type of autoinflammatory skin disease.

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community Blaming Finasteride doesn't help you solve anything: dry eyes

in Finasteride/Dutasteride 51 upvotes 8 months ago

Finasteride is debated for causing dry eyes, with some users experiencing relief after stopping it, while others find no connection. Topical treatments like dutasteride and minoxidil are suggested as alternatives, with advice to consult medical professionals.