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    Glossary Keratinization

    process where skin cells produce keratin and become tough

    Keratinization, also known as cornification, is the biological process by which keratin, a protective protein, is produced and accumulated in cells of the epidermis, the outermost layer of the skin. This process results in the formation of a tough, protective layer of dead cells that helps to prevent water loss and protect against environmental damage, pathogens, and physical abrasion.

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    1. Keratinization and its Disorders Oman Medical Journal · 2012 · 95 citations
    2. Increased expression of keratin 16 causes anomalies in cytoarchitecture and keratinization in transgenic mouse skin. The Journal of Cell Biology · 1994 · 94 citations
    3. Patterns of epithelial expression of Fos protein suggest important role in the transition from viable to cornified cell during keratinization Development · 1991 · 83 citations
    4. Structural and Immunocytochemical Characterization of Keratinization in Vertebrate Epidermis and Epidermal Derivatives International review of cytology · 2006 · 82 citations
    5. The Process of Cornification Evolved From the Initial Keratinization in the Epidermis and Epidermal Derivatives of Vertebrates: A New Synthesis and the Case of Sauropsids International review of cell and molecular biology · 2016 · 73 citations
    6. Outer root sheath keratinization in anagen and catagen of the mammalian hair follicle. A seventh distinct type of keratinization in the hair follicle: trichilemmal keratinization. PubMed · 1981 · 59 citations
    7. Embryonic keratinization in vertebrates in relation to land colonization Acta Zoologica · 2008 · 44 citations
    8. Disorders of Keratinization American journal of clinical dermatology · 2004 · 44 citations
    9. Hidradenitis Suppurativa as a Potential Subtype of Autoinflammatory Keratinization Disease Frontiers in immunology · 2020 · 41 citations
    10. Retinoids and Keratinization International Journal of Dermatology · 1988 · 32 citations
    11. Spiny keratoderma ‐ a demonstration of hair keratin and hair type keratinization Journal of Cutaneous Pathology · 1999 · 30 citations
    12. Study of the keratinization process in human hair follicle by X-ray microdiffraction. PubMed · 2000 · 28 citations
    13. Keratinization of sheath and calamus cells in developing and regenerating feathers Annals of Anatomy - Anatomischer Anzeiger · 2007 · 26 citations
    14. Structural changes in trichocyte keratin intermediate filaments during keratinization Journal of Structural Biology · 2003 · 23 citations
    15. Effects of cepharanthine and minoxidil on proliferation, differentiation and keratinization of cultured cells from the murine hair apparatus Archives of Dermatological Research · 1992 · 23 citations
    16. HAIR KERATINIZATION IN HEALTH AND DISEASE Dermatologic clinics · 1996 · 22 citations
    17. Molecular Genetics of Keratinization Disorders – What’s New About Ichthyosis Acta dermato-venereologica · 2020 · 18 citations
    18. Glycoconjugate expression of cells of human anagen hair follicles during keratinization The Anatomical Record · 1990 · 12 citations
    19. Ultrastructure of the contrasting types of keratinization seen in the tail epidermis of the laboratory mouseMus musculus Archives of dermatological research · 1977 · 11 citations
    20. A Heritable Keratinization Defect of the Superficial Epidermis in Norfolk Terriers Journal of Comparative Pathology · 2004 · 11 citations
    21. Keratinization of outer root sheath cells is prevented by contact with inner root sheath of rat hair follicles Archives of Dermatological Research · 2008 · 9 citations
    22. Pili Trianguli et Canaliculi Is a Defect of Inner Root Sheath Keratinization 2005 · 8 citations
    23. Key Factors in the Complex and Coordinated Network of Skin Keratinization: Their Significance and Involvement in Common Skin Conditions International journal of molecular sciences · 2023 · 2 citations
    24. Artificial Infestation of Sarcoptes scabiei (Acari: Sarcoptidae) in Rabbits Exhibits Progressive Pathological Changes, Apoptosis, and Keratinization in the Skin International journal of molecular sciences · 2023 · 1 citations
    25. Transcriptomics sequencing reveals Qu-shi-yu-fa Decoction promotes hair cycle and keratinization by upregulating FOXN1 and TGM3 to treat androgenetic alopecia Phytomedicine · 2025
    26. Qu-Shi-Yu-Fa Decoction Promotes Hair Cycle and Keratinization by Upregulating Foxn1 and Tgm3 to Treat Androgenetic Alopecia 2024
    27. Keratosis Pilaris Is a Keratinization of Hair Follicles International journal of integrated medical research · 2023
    28. Faculty Opinions recommendation of Hidradenitis suppurativa as a potential subtype of autoinflammatory keratinization disease. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2020
    29. Disorders of Keratinization 2014
    30. Keratinisation status and cytokeratins of the human Meibomian gland epithelium Acta Ophthalmologica · 2009 · 5 citations