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GlossaryKeratinization Disorders

abnormal keratin production causing skin, hair, and nail issues

Keratinization disorders are conditions where the process of keratinization, the formation of the protein keratin in the skin, hair, and nails, is abnormal. This can lead to symptoms like thickened skin, scaling, and other skin abnormalities. Examples include psoriasis and ichthyosis, where the skin cells produce too much keratin or shed improperly, causing visible and sometimes uncomfortable skin changes.

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research Molecular Genetics of Keratinization Disorders: What's New About Ichthyosis

18 citations, January 2020 in “Acta dermato-venereologica”

Over 67 genes linked to ichthyosis help improve diagnosis and treatment.

research Disorders of Keratinization

November 2014

The chapter explains that there are many genetic skin disorders affecting skin cell formation, including both common and rare types.

research Psoriasis, Acne, and Disorders of Keratinization

July 2003 in “Journal of Cutaneous Medicine and Surgery”

Treating psoriasis with UVB light three times a week is faster than twice a week, and certain medications and lifestyle factors affect psoriasis treatment outcomes.

research Widespread Porokeratotic Adnexal Ostial Nevus: Clinical Features and Proposal of a New Name Unifying Porokeratotic Eccrine Ostial and Dermal Duct Nevus and Porokeratotic Eccrine and Hair Follicle Nevus

60 citations, August 2009 in “Journal of the American Academy of Dermatology”

The term "porokeratotic adnexal ostial nevus" is proposed to unify overlapping skin conditions involving eccrine and hair follicles.

research Dermatological Aspects of the S2k Guidelines on Down Syndrome in Childhood and Adolescence

10 citations, October 2018 in “JDDG Journal der Deutschen Dermatologischen Gesellschaft”

Most skin conditions in Down syndrome are benign and involve dry or thickened skin.

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