An Investigation of Keratin 15 Function by Small Interfering RNA Technology

    January 2012 in “ Durham e-Theses (Durham University) ”
    Cheryl Lancaster
    Image of study
    TLDR Keratin 15 affects cell behavior and characteristics in skin cells.
    The study investigated the role of keratin 15 (K15) in maintaining the stem cell niche by using siRNA to knock down K15 in various cell lines. It was found that K15 knock-down did not affect cell adhesion but did influence cell spreading, morphology, migration, differentiation, and proliferation. Specifically, K15-deficient cells spread more quickly, were larger, less motile, showed increased differentiation as indicated by higher involucrin expression, and proliferated more than control cells. K15 was present in the basal layers of the epidermis and around hair follicles in rat, mouse, and human skin. The study concluded that K15 impacts the stem cell characteristics of keratinocytes, though further research was needed to understand the underlying mechanisms.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 190 results

      community A Decade on Hairloss Battle

      in Progress  10 upvotes 6 years ago
      The post discusses a 10-year battle with hair loss using treatments like biotin, Rogaine, Dualgen 15% Minoxidil, dermaroller, and various skin care products. Despite some side effects, the user maintains a full head of hair and is considering a hair transplant in the future.

      community 15-Month Update - Dut, Min, Niz, 1.5mm Roller.

      in Progress Pictures  318 upvotes 2 years ago
      The user shared a 15-month hair loss treatment update using Dutasteride (0.5mg/day), Minoxidil (5% foam twice daily), Nizoral (1% every 3 days), and a 1.5mm derma roller (twice a month), along with a multivitamin, exercise, low sugar diet, hydration, and consistent sleep. They started seeing results after 6-9 months, with significant improvement at the 1-year mark, and apply Minoxidil the day after derma rolling.

      community Discussion: Keratin Microsphere Results

      in Treatment  30 upvotes 2 years ago
      Keratin microspheres may offer additional mechanisms to combat hair loss compared to minoxidil. The process to create these microspheres is relatively simple and can be done at home with basic equipment.

      community 5 Months Finasteride + Minoxidil

      in Progress Pictures  676 upvotes 3 years ago
      This user has achieved impressive results after 5 months of using Finasteride and Minoxidil, which appear to have stopped hair loss and stimulated new growth. They have also incorporated derma pen treatments and supplements such as Zinc picolinate and DMAE into their regimen.

    Similar Research

    5 / 1000+ results