Correction of Hair Shaft Defects Through Allele-Specific Silencing of Mutant Krt75

    September 2015 in “ Journal of Investigative Dermatology ”
    Ying Liu, Elizabeth R. Snedecor, Xu Zhang … Chen Chen Jiang
    Studysummary This study demonstrated that RNA interference targeting mutant keratin genes can effectively correct hair shaft structural defects in a mouse model by reducing mutant gene expression.
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    Research cited in this study 12

    1. Keratins and Skin Disease: Genetic and Molecular Roles Cell & tissue research/Cell and tissue research · 2015
    2. Genetics of Structural Hair Disorders Journal of Investigative Dermatology · 2012
    3. The Chicken Frizzle Feather Is Due to an Alpha-Keratin (KRT75) Mutation That Causes a Defective Rachis PLoS Genetics · 2012
    4. Keratin Disorders: From Gene to Therapy Human molecular genetics online/Human molecular genetics · 2011
    5. Cytokeratin 15 Expression in Central, Centrifugal, Cicatricial Alopecia: New Observations in Normal and Diseased Hair Follicles Journal of Cutaneous Pathology · 2011
    6. Isolation and Short-Term Culture of Primary Keratinocytes, Hair Follicle Populations, and Dermal Cells from Newborn Mice and Keratinocytes from Adult Mice for In Vitro Analysis and Grafting to Immunodeficient Mice Nature Protocols · 2008
    7. Mice Expressing a Mutant KRT75 (K6hf) Allele Develop Hair and Nail Defects Resembling Pachyonychia Congenita Journal of Investigative Dermatology · 2007
    8. Hair Follicle-Specific Keratins And Their Diseases Experimental cell research · 2007
    9. An Unusual Ala12Thr Polymorphism in the 1A Alpha-Helical Segment of the Companion Layer-Specific Keratin K6hf: Evidence for a Risk Factor in the Etiology of the Common Hair Disorder Pseudofolliculitis Barbae Journal of Investigative Dermatology · 2004
    10. Is Loose Anagen Hair Syndrome a Keratin Disorder? Archives of Dermatology · 2002
    11. Discovery of a Novel Murine Keratin 6 (K6) Isoform Explains the Absence of Hair and Nail Defects in Mice Deficient for K6a and K6b The Journal of Cell Biology · 2001
    12. A Novel Human Type II Cytokeratin, K6hf, Specifically Expressed in the Companion Layer of the Hair Follicle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998

    Related research 2

    1. Correction of Hair Shaft Defects Through Allele-Specific Silencing of Mutant Krt75 Journal of Investigative Dermatology · 2015
    2. Keratin and Skin Disorders Cell biology international · 1996