Genetics of Structural Hair Disorders

    November 2012 in “ Journal of Investigative Dermatology ”
    Sivan Harel, Angela M. Christiano
    Image of study
    TLDR The document concludes that over 500 genes are linked to hair disorders and this knowledge is important for creating new treatments.
    The document from 2012 reviews the genetic underpinnings of structural hair disorders, identifying over 500 genes associated with skin and hair abnormalities. It details how specific mutations in keratin genes lead to conditions such as monilethrix and ectodermal dysplasia, while mutations in desmosomal proteins and lipid-related genes are linked to hypotrichosis and woolly hair syndromes. Mutations in the HR and APCDD1 genes cause atrichia and hereditary hypotrichosis simplex, respectively. The review also notes that gene positioning can affect hair growth, as seen with TRPS1 gene rearrangements causing hypertrichosis. Furthermore, it discusses the role of Trps1 in trichorhinophalangeal syndromes and how mutations near SOX9 or affecting SOX3 can lead to hypertrichosis. This genetic knowledge is crucial for developing new treatments for hair disorders and may also inform our understanding of related skin conditions. The authors report no conflicts of interest.
    Discuss this study in the Community →

    Research cited in this study

    14 / 14 results

    Related Community Posts Join

    6 / 101 results

      community Keratin microspheres - breakthrough

      in Research/Science  13 upvotes 8 months ago
      A gel of keratin microspheres promotes hair follicle growth, showing similar effectiveness to minoxidil in mice. The treatment activates hair growth pathways and reduces inflammation, with potential applications in drug delivery for hair-related disorders.

      community Results of Procyanidin B2 in clinical studies

      in Treatment  13 upvotes 4 years ago
      Procyanidin B2, a compound derived from Annurca apples, as a potential treatment for pattern hair loss. Several clinical studies were mentioned, which found that procyanidin B2 could increase hair growth, density, and keratin content. Other treatments such as Minoxidil, Finasteride, and RU58841 were not discussed.

      community 1ish year on fin and no improvement

      in Is this regrowth?  86 upvotes 1 month ago
      The user has been using finasteride for over a year without improvement and recently started oral minoxidil. Suggestions include trying dutasteride and continuing minoxidil for potential regrowth.

      community HT / Meds results are reverting, thinning, crazy shedding..

      in Progress Pictures  162 upvotes 2 months ago
      A user experienced significant hair shedding and thinning 10 months post-hair transplant despite using minoxidil and topical finasteride. They are considering switching to oral finasteride or dutasteride and are also dealing with scalp conditions like seborrheic dermatitis.

      community I'm sorry I hate it, I cannot enjoy life like this.

      in Chat  175 upvotes 2 months ago
      A 22-year-old male is frustrated about being the only bald person in his social circle. He has tried minoxidil, finasteride, and dutasteride without success and is considering hair systems, transplants, or counseling.

    Similar Research

    5 / 1000+ results
      Biology and Genetics of Hair

      research Biology and Genetics of Hair

      89 citations, September 2010 in “Annual Review of Genomics and Human Genetics”
      The document concludes that understanding the genes and pathways involved in hair growth is crucial for developing treatments for hair diseases.
      Current Genetics in Hair Diseases

      research Current Genetics in Hair Diseases

      1 citations, February 2013 in “InTech eBooks”
      Genetic mutations cause various hair diseases, and whole genome sequencing may reveal more about these conditions.
      Molecular Genetics of Alopecias

      research Molecular Genetics of Alopecias

      9 citations, January 2015 in “Current problems in dermatology”
      Scientists have found specific genes linked to different hair loss conditions, which could lead to new treatments.