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    Glossary Hereditary Hypotrichosis Simplex

    genetic condition causing progressive hair thinning and loss

    Hereditary Hypotrichosis Simplex (HHS) is a genetic condition characterized by progressive hair thinning and loss, typically beginning in childhood or adolescence. Unlike other forms of hair loss, HHS does not involve scarring or other skin abnormalities, and it primarily affects the scalp, leading to sparse or absent hair over time.

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    1. APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex Nature · 2010 · 199 citations
    2. A new locus for hereditary hypotrichosis simplex maps to chromosome 13q12.12∼12.3 in a Chinese family Journal of Cutaneous Pathology · 2010 · 7 citations
    3. Isotretinoin-induced hair growth in a case of hereditary hypotrichosis simplex of the scalp: A promising therapeutic approach JAAD Case Reports · 2024
    4. Successful treatment of hereditary hypotrichosis simplex by platelet rich plasma injection with topical minoxidil 2% Journal of Dermatological Treatment · 2023
    5. Treatment of hereditary hypotrichosis simplex of the scalp with oral minoxidil and growth factors Dermatologic Therapy · 2022
    6. Autosomal recessive hereditary hypotrichosis simplex: A case report JAAD Case Reports · 2024
    7. Autosomal recessive hypotrichosis simplex with woolly hair: a report of a new family Dermatology Reports · 2011 · 1 citations
    8. Mutations in SNRPE, which Encodes a Core Protein of the Spliceosome, Cause Autosomal-Dominant Hypotrichosis Simplex The American Journal of Human Genetics · 2012 · 39 citations
    9. Genetics of Structural Hair Disorders Journal of Investigative Dermatology · 2012 · 17 citations
    10. Inherited Disorders of the Hair Elsevier eBooks · 2013 · 2 citations
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