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Did you mean Hair Shaft Defects?

Glossary Hair Shaft Defects

refer to structural abnormalities in hair strands

Hair Shaft Defects refer to abnormalities in the structure of the hair strand that can lead to issues like brittleness, breakage, and an overall unhealthy appearance. These defects can be caused by genetic conditions, environmental damage, or improper hair care practices, and they often require specific treatments or changes in hair care routines to manage effectively.

Related Terms

Research

5 / 1000+ results

research Hair Defects and Pup Loss in Mice with Targeted Deletion of the First Cut Repeat Domain of theCux/CDPHomeoprotein Gene

48 citations , August 1998 in “Developmental Biology”

In this study, researchers created a mutant mouse lacking the first cut repeat in the Cux/CDP protein, resulting in curly vibrissae and wavy hair, supporting the role of Cux/CDP's DNA binding domains in gene regulation during development.

research Correction of Hair Shaft Defects through Allele-Specific Silencing of Mutant Krt75

6 citations , September 2015 in “Journal of Investigative Dermatology”

This study demonstrated that RNA interference targeting mutant keratin genes can effectively correct hair shaft structural defects in a mouse model by reducing mutant gene expression.

research MULTIPLE DEFECTS OF THE HAIR SHAFT IN NETHERTON'S DISEASE.

58 citations , November 1969 in “British Journal of Dermatology”

This report describes two patients with ichthyosis linearis circumflexa exhibiting symptoms resembling Netherton's disease, noting multiple hair shaft defects and discussing a possible connection to aminoaciduria.

research Letter: Re: Hair Transplantation for Reconstruction of Scalp Defects Using Artificial Dermis

July 2012 in “Dermatologic Surgery”

The author believes artificial dermis might not be the best first option for hair transplant surgeons when other surgical choices exist for scalp reconstruction.

research Keratinocyte growth factor is an important endogenous mediator of hair follicle growth, development, and differentiation. Normalization of the nu/nu follicular differentiation defect and amelioration of chemotherapy-induced alopecia.

219 citations , July 1995 in “PubMed”

This study found that recombinant keratinocyte growth factor (rKGF) stimulated hair growth and provided a protective effect against alopecia in murine models, suggesting its role in hair follicle development and regeneration.

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Community Join

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community The road to recovering my mane

5 upvotes 8 months ago

The user experienced hair loss due to defective dutasteride and is now using a regimen including dutasteride, oral and topical minoxidil, RU58841, tretinoin, and microneedling to recover hair density. They are optimistic about regaining their hair despite recent setbacks.

community REGROWTH AFTER 12 YEARS! My doctor approves of self-prescribed gray market internet dutasteride!!

in Female 72 upvotes 1 year ago

A woman experienced hair regrowth after using self-prescribed finasteride and dutasteride from online sources, despite doctors' reluctance to prescribe these due to potential birth defects. Her dermatologist acknowledged the effectiveness of these treatments and advised her to continue using them while avoiding pregnancy.

community Don’t do like me. Don’t take a long break from Fin and Min

in Chat 124 upvotes 10 months ago

Stopping finasteride and minoxidil can cause significant hair shedding, so they should be continued indefinitely. Concerns about finasteride affecting fertility or causing birth defects are mostly unfounded, but some stop for personal reasons.

community DHT Isn’t the Only Factor in Hair Loss and That Might Be the Key to a Real Cure

373 upvotes 6 months ago

Hair loss involves more than just DHT, with genetic factors like TRPS affecting hair follicles. Treatments such as Amplifica's AMP-601 and AMP-303 target stem cells for potential hair growth solutions.

community New Hair Loss Cure: AMP-303 Is Back. It’s what PP405 should have been.

7 upvotes 5 months ago

AMP-303 and AMP-601 are new hair loss treatments targeting dermal papilla cells, with AMP-303 showing early efficacy in transitioning vellus hairs to terminal hairs after one injection. Further clinical trials are planned, and these treatments are seen as promising due to their biologic approach and less frequent application compared to daily treatments.

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