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Glossary Lentivirus

virus that integrates into host DNA, used in gene therapy

A lentivirus is a type of virus that belongs to the retrovirus family and is known for its ability to infect and integrate into the DNA of host cells. These viruses can cause long-term, chronic infections and are used in gene therapy due to their ability to deliver genetic material into cells. HIV (Human Immunodeficiency Virus) is a well-known example of a lentivirus.

Research

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research Efficient In Vivo Targeting of Epidermal Stem Cells by Early Gestational Intraamniotic Injection of Lentiviral Vector Driven by the Keratin 5 Promoter

52 citations , October 2007 in “Molecular Therapy”

Injecting lentiviral vectors into early gestation mice effectively targets skin stem cells for potential gene therapy.

research Efficient expansion of human keratinocyte stem/progenitor cells carrying a transgene with lentiviral vector

18 citations , October 2013 in “Stem Cell Research & Therapy”

This study found that combining polybrene and a ROCK inhibitor can effectively expand human keratinocyte stem/progenitor cells carrying a transgene, aiding their use in regenerative medicine.

research Lentiviral Arrays for Live-cell Dynamic Monitoring of Gene and Pathway Activity During Stem Cell Differentiation

13 citations , June 2014 in “Molecular therapy”

This study found that a lentiviral array of reporters can identify lineage-specific promoters and pathways in mesenchymal stem cell differentiation, aiding in the prediction of signaling pathway effects.

research Characterization of factors that determine lentiviral vector tropism in skin tissue using an ex vivo model

7 citations , March 2011 in “The Journal of Gene Medicine”

This study found that lentiviral vector tropism in three-dimensional skin tissue is distinct from keratinocytes in culture and is influenced by complex extracellular interactions.

research Lentivirus‐mediated subcutaneous JAM‐A modification promotes skin wound healing in a mouse model by strengthening the secretory function and proliferation of fibroblasts

5 citations , April 2022 in “Cell Biology International”

This study found that JAM-A modification in mouse wound models significantly promoted wound healing and fibroblast proliferation, potentially linked to increased levels of growth factors bFGF and EGF.

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