Th22 Is the Effector Cell of Thymosin β15-Induced Hair Regeneration in Mice

January 2024 in “ Inflammation and regeneration ”

Nana Tao, Yuyuan Ying, X Xu, Qingru Sun, Yongqian Shu, Shiyu Hu, Zhaohuan Lou, Jian‐Li Gao

thymosin beta 15 Tβ15 Th22 cells hair regeneration hair follicle cell proliferation IL-22BP inhibitor adenovirus lentivirus

TLDR Th22 cells are essential for Tβ15-induced hair growth in mice.

The study demonstrates that thymosin β15 (Tβ15) significantly promotes hair regeneration in mice by increasing the number and activity of Th22 cells around hair follicles. Overexpression of Tβ15 enhances hair follicle cell proliferation and maturation, while blocking Th22 activity or knocking down Tβ15 inhibits hair growth. The findings suggest that Tβ15 and Th22 cells are crucial for hair regeneration and could be potential drug targets for treating hair loss.

View this study on inflammregen.biomedcentral.com →

Discuss this study in the Community →

Research cited in this study

14 / 14 results

Injury-Induced Interleukin-1 Alpha Promotes Lgr5 Hair Follicle Stem Cells Regeneration and Proliferation via Regulating Regenerative Microenvironment in Mice

research Injury-Induced Interleukin-1 Alpha Promotes Lgr5 Hair Follicle Stem Cells Regeneration and Proliferation via Regulating Regenerative Microenvironment in Mice

7 citations, February 2023 in “Inflammation and Regeneration”

The protein interleukin-1 alpha helps regenerate hair follicles and increase stem cell growth in mice.

research Alpinetin Promotes Hair Regeneration via Activating Hair Follicle Stem Cells

11 citations, May 2022 in “Chinese medicine”

Alpinetin helps grow hair by turning on hair stem cells and is safe for use.

P63 Targeted Deletion Under the FOXN1 Promoter Disrupts Pre- and Post-Natal Thymus Development, Function, and Maintenance, and Induces Severe Hair Loss

research P63 Targeted Deletion Under the FOXN1 Promoter Disrupts Pre- and Post-Natal Thymus Development, Function, and Maintenance, and Induces Severe Hair Loss

5 citations, January 2022 in “PloS one”

Deleting the p63 gene in certain cells causes problems in thymus development and severe hair loss in mice.

research Epidermal Stem Cells in Hair Follicle Cycling and Skin Regeneration: A View From the Perspective of Inflammation

18 citations, November 2020 in “Frontiers in Cell and Developmental Biology”

Inflammation plays a key role in activating skin stem cells for hair growth and wound healing, but more research is needed to understand how it directs cell behavior.

The Overexpression of Tβ4 in the Hair Follicle Tissue of Alpas Cashmere Goats Increases Cashmere Yield and Promotes Hair Follicle Development

research The Overexpression of Tβ4 in the Hair Follicle Tissue of Alpas Cashmere Goats Increases Cashmere Yield and Promotes Hair Follicle Development

16 citations, December 2019 in “Animals”

Overexpressing Tβ4 in goats' hair follicles increases cashmere production and hair follicle growth.

research Alopecia Diffusa While Using Interleukin-17 Inhibitors Against Psoriasis Vulgaris

20 citations, March 2019 in “Case Reports in Dermatology”

IL-17 inhibitors for psoriasis may cause unexpected hair loss.

research Use of Human Intra-Tissue Stem/Progenitor Cells and Induced Pluripotent Stem Cells for Hair Follicle Regeneration

17 citations, February 2019 in “PubMed”

Stem cells can help regenerate hair follicles.

research New Pattern Hair Loss in Young Turkish Women: What's Wrong in Their Daily Life?

3 citations, January 2019 in “Skin Research and Technology”

Frequent use of hair straighteners can cause hair loss similar to scarring alopecia in young Turkish women.

research Therapeutic Potential of Stem Cells in Follicle Regeneration

45 citations, August 2018 in “Stem Cells International”

Stem cells, especially from fat tissue and Wharton's jelly, can potentially regenerate hair follicles and treat hair loss, but more research is needed to perfect the treatment.

research Tβ4-Overexpression Based on the PiggyBac Transposon System in Cashmere Goats Alters Hair Fiber Characteristics

18 citations, November 2016 in “Transgenic research”

Overexpressing Tβ4 in cashmere goats improves hair fiber traits and increases cashmere yield.

Decoction and Fermentation of Selected Medicinal Herbs Promote Hair Regrowth by Inducing Hair Follicle Growth in Conjunction with Wnt Signaling

research Decoction and Fermentation of Selected Medicinal Herbs Promote Hair Regrowth by Inducing Hair Follicle Growth in Conjunction with Wnt Signaling

6 citations, January 2016 in “Evidence-based Complementary and Alternative Medicine”

Boiling and fermenting certain herbs can help hair grow by activating hair growth genes and pathways.

research Over-Expression of Thymosin Beta4 Promotes Abnormal Tooth Development and Stimulation of Hair Growth

34 citations, December 2009 in “The International Journal of Developmental Biology”

Too much thymosin beta4 causes weird teeth and more hair growth in mice.

research The Hair Follicle as a Dynamic Mini-Organ

759 citations, February 2009 in “Current Biology”

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

research Thymosin Beta 4 Increases Hair Growth by Activation of Hair Follicle Stem Cells

98 citations, December 2003 in “The FASEB Journal”

Thymosin β4 promotes hair growth by activating stem cells in hair follicles.

Related Research

4 / 4 results

Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles