Th22 Is the Effector Cell of Thymosin β15-Induced Hair Regeneration in Mice

January 2024 in “ Inflammation and regeneration ”

Nana Tao, Yuyuan Ying, X Xu, Qingru Sun, Yongqian Shu, Shiyu Hu, Zhaohuan Lou, Jian‐Li Gao

thymosin beta 15 Tβ15 Th22 cells hair regeneration hair follicle cell proliferation IL-22BP inhibitor adenovirus lentivirus

TLDR Th22 cells are essential for Tβ15-induced hair growth in mice.

The study demonstrates that thymosin β15 (Tβ15) significantly promotes hair regeneration in mice by increasing the number and activity of Th22 cells around hair follicles. Overexpression of Tβ15 enhances hair follicle cell proliferation and maturation, while blocking Th22 activity or knocking down Tβ15 inhibits hair growth. The findings suggest that Tβ15 and Th22 cells are crucial for hair regeneration and could be potential drug targets for treating hair loss.

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