Alopecia Diffusa While Using Interleukin-17 Inhibitors Against Psoriasis Vulgaris

    March 2019 in “ Case Reports in Dermatology ”
    Makiko Yajima, Tomoko Akeda, Makoto Kondo, Koji Habe, Keiichi Yamanaka
    TLDR IL-17 inhibitors for psoriasis may cause unexpected hair loss.
    The document reported two cases of alopecia diffusa occurring during the treatment of psoriasis vulgaris with interleukin (IL)-17 inhibitors. Both patients, a 62-year-old female and a 40-year-old female, experienced significant hair loss after starting IL-17 inhibitor treatments (secukinumab and brodalumab, respectively). The hair loss was reversed in the first patient with the addition of oral prednisolone and in the second patient by switching to ustekinumab, an IL-12/23 p40 inhibitor. The study suggested that the paradoxical reaction of alopecia might be due to the conversion of the Th17/Th1 axis into a Th1-dominant immune status, leading to hair follicle destruction. The authors concluded that more cases need to be accumulated to understand this phenomenon better.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 1000+ results

      community How insane is this oral min shed?

      in Progress Pictures  111 upvotes 2 years ago
      A user started taking 0.625mg oral minoxidil daily for hair loss, increased the dose to 1.25mg, and experienced a significant shed, losing 70% of scalp density. They cannot tolerate finasteride due to side effects but are hopeful for hair regrowth despite the shedding.

      community How much do you guys think diet and sleep affects results?

      in Research/Science  38 upvotes 2 years ago
      The conversation discusses whether lifestyle factors like diet and sleep affect hair growth in people with reversible hair loss. Some believe these factors, along with treatments like minoxidil, finasteride, and RU58841, can improve hair health, while others argue hair loss is mostly determined by genetics and DHT sensitivity.

      community My experience and a discourse on “DUPA”

      in Chat  46 upvotes 3 years ago
      How diffuse unpatterned alopecia (DUPA) is not an invitation to self-diagnose oneself with aggressive AGA and that seeking a specialized dermatologist may help people experiencing hair loss. Treatment options discussed include topical clobetasol propionate, oral minoxidil, and discontinuing finasteride.

      community Fuck hair loss; acquire beard.

      in Shaved/buzzed  929 upvotes 3 years ago
      A user's transformation from an accountant to a spartan with a full beard, discussing the potential of DUPA and alopecia areata, as well as treatments like vitamins, topicals, and natural treatments for potential regrowth.

    Related Research

    3 / 3 results