IL-17 Inhibition: Is It the Long-Awaited Savior for Alopecia Areata?
March 2018
in “
Archives of Dermatological Research
”
Research cited in this study
37 / 37 results
research Alopecia Areata: A Comprehensive Review of Pathogenesis and Management
This review noted that alopecia areata is an autoimmune disease impacting hair follicles and offered insights into its complex pathogenesis involving immune responses, while highlighting ongoing research into new treatments such as Janus kinase inhibitors and other immunomodulatory drugs.
research The Changing Landscape of Alopecia Areata: The Therapeutic Paradigm
This review discusses recent advances and ongoing clinical trials in novel therapeutics for alopecia areata, despite the lack of current FDA-approved treatments for severe cases, and reports no new results.
research The Changing Landscape of Alopecia Areata: The Translational Landscape
This review summarizes recent research on alopecia areata, highlighting advances in targeted therapies due to improved understanding of its immunopathogenesis, though it reports no new clinical results.
research Janus Kinase Inhibitors in Dermatology: A Systematic Review
This systematic review found that Janus kinase inhibitors have shown beneficial effects for psoriasis and alopecia areata, with promising preliminary results in other skin conditions, though more research is needed to define dosing and safety profiles.
research Efficacy of Tofacitinib in Treatment of Alopecia Universalis in Two Patients
In this study, tofacitinib treatment was associated with significant hair regrowth in two patients with alopecia universalis over eight months, with minimal adverse effects reported.
research Familial Aggregation of Alopecia Areata
This review examines the immunological aspects of alopecia areata, focusing on genetic, neuroimmunological, and immune privilege factors, but does not report new clinical findings.
research A Novel Therapeutic Paradigm for Patients with Extensive Alopecia Areata
This review discusses immune pathways involved in alopecia areata and explores emerging, more targeted therapeutic strategies, noting their potential for better safety and effectiveness compared to traditional immune suppressants.
research The Many Faces of Interleukin-17 in Inflammatory Skin Diseases
This article reviews the role of IL-17 in inflammatory skin disorders and highlights its potential therapeutic targeting in both neutrophilic and lymphocyte-mediated conditions, reporting no new experimental results.
research Treatment of an Alopecia Areata Patient with Tofacitinib Results in Regrowth of Hair and Changes in Serum and Skin Biomarkers
In this study, oral tofacitinib treatment led to significant hair regrowth and changes in skin and blood biomarkers in a patient with alopecia areata.
research Transient Efficacy of Tofacitinib in Alopecia Areata Universalis
This study observed initial hair regrowth in a businessman with alopecia areata universalis treated with tofacitinib, but the effect diminished, leading to renewed hair loss.
research A Systematic Review of Pulse Steroid Therapy for Alopecia Areata
This systematic review of pulse corticosteroid therapy for alopecia areata found relatively low complete response rates, but responders experienced low relapse rates, indicating potential benefits for patients with favorable prognostic factors.
research Alopecia Areata Profiling Shows TH1, TH2, and IL-23 Cytokine Activation Without Parallel TH17/TH22 Skewing
This study identified a distinct cytokine activation signature in alopecia areata, involving TH2, TH1, IL-23, and IL-9/TH9 pathways, suggesting potential targeting strategies similar to those in psoriasis and atopic dermatitis.
research Imbalance of T-Helper 17 and Regulatory T Cells in Patients with Alopecia Areata
This study found that patients with alopecia areata had higher levels of Th17 cells and lower levels of regulatory T cells compared to healthy controls, suggesting an immune imbalance in these patients.
research Translational Positioning of Janus Kinase (JAK) Inhibitors in Alopecia Areata
This research highlights that JAK inhibitors, such as baricitinib, may effectively reverse symptoms of alopecia areata by targeting specific immune pathways, though safety and efficacy require further investigation.
research Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib
This study observed that baricitinib treatment led to significant improvement in a patient's alopecia areata symptoms and suggests further clinical trials to explore its potential as a treatment.
research The Genetics Of Alopecia Areata: New Approaches, New Findings, New Treatments
This review summarizes the current genetic research on alopecia areata, including potential new therapeutic strategies, but reports no new clinical findings.
research Molecular Genetics of Alopecias
This review highlights recent genetic research advancements in understanding hereditary hair diseases but reports no new study results, emphasizing the identification of genes related to both monogenic and polygenic hair disorders.
research Inhibiting Janus Kinases to Treat Alopecia Areata
JAK inhibitors might help treat alopecia areata.
research Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition
This study found that JAK inhibitors promote hair regrowth in both mice and human alopecia areata cases by blocking key immune pathways involved in disease development.
research Killing Two Birds with One Stone: Oral Tofacitinib Reverses Alopecia Universalis in a Patient with Plaque Psoriasis
This case report describes complete hair regrowth in a patient with alopecia universalis and improved psoriasis after treatment with the oral Janus kinase inhibitor, tofacitinib.
research Endogenous Retinoids in the Pathogenesis of Alopecia Areata
This study suggests that vitamin A influences the immune response and hair cycle, affecting the progression of alopecia areata in mouse models.
research Alopecia Areata: An Autoimmune Disease Causing Hair Loss
Alopecia Areata is an autoimmune condition causing hair loss with no cure and treatments that often don't work well.
research Advances in the Management of Alopecia Areata
This review discusses updated treatment guidelines for alopecia areata in Japan, highlighting new options like corticosteroid pulse therapy, but reports no new clinical results.
research Renbök Phenomenon in a Patient with Alopecia Areata Universalis and Psoriasis
This abstract provides clinical images of scaly erythematous lesions but does not report any new research findings; further queries should be directed to the corresponding author.
research Treatment of Alopecia Areata: What Is New on the Horizon?
This review discusses potential new drug treatment strategies for alopecia areata based on genome-wide association study findings, but it reports no new clinical results.
research Topical and Intralesional Therapies for Alopecia Areata
This review discusses topical and intralesional treatments for alopecia areata, providing a management strategy based on patient age and disease severity, but reports no new clinical results.
research Histopathology of Alopecia Areata, Acute and Chronic: Why Is It Important to the Clinician?
This article discusses the phases and histological features of alopecia areata and reports no new clinical findings; the authors emphasize recognizing these phases for accurate diagnosis.
research Alopecia Universalis Following Two Sequential Traffic Accidents: Possible Association with Increased Th1 and Th17 Cells and Decreased Th2 Cells
In this case study, the progression of alopecia universalis in a Japanese man was linked to the involvement of Th1 and Th17 cells, suggesting an autoimmune mechanism.
research Generalized Vitiligo Associated Autoimmune Diseases in Japanese Patients and Their Families
Among Japanese patients with generalized vitiligo, this study found a genetic susceptibility to autoimmune diseases, particularly autoimmune thyroid disease, within families.
research Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity
This study identified key genetic regions associated with alopecia areata, highlighting both acquired and innate immune involvement, with a novel link to the upregulation of ULBP ligands in autoimmune disease.
research Alopecia Areata Update
This review discusses treatment options for alopecia areata and suggests tailored treatment plans, noting the challenges posed by spontaneous remission and limited high-quality clinical trials.
research Alopecia Areata Update
This article reviews the clinical presentation and histopathologic features of alopecia areata and proposes a hypothesis for its development, but it reports no new clinical results.
research Intralesional Steroids for Alopecia Areata
Intralesional steroids can help regrow hair in some alopecia areata patients but have side effects.
research Neuroendocrine Perspectives in Alopecia Areata: Does Stress Play a Role?
This research highlights that psychological stress can adversely affect hair growth in mice, implicating potential pathways that may be relevant in understanding stress-induced hair growth inhibition in humans.
research Lymphocytes, Neuropeptides, And Genes Involved In Alopecia Areata
This review examines the interplay of genetics and neuroimmunology in alopecia areata, highlighting its potential to inform broader autoimmunity research, but reports no new findings.
research Alopecia Areata: Overview and Treatment Options
This review explores the causes and mechanisms of alopecia areata and discusses current treatments, reporting no new clinical findings.
research Alopecia Areata: A Tissue-Specific Autoimmune Disease of the Hair Follicle
This review discusses alopecia areata as a model for studying tissue-directed autoimmune diseases and reports no new clinical findings.
Similar Research
6 / 1000+ resultsresearch Predominant expression of interleukin (IL)‐17 in chronic alopecia areata compared to IFN‐γ in pathogenic Th17 cells, tissue‐resident memory T cells and natural killer cells
This study suggests that IL-17 may play a more significant role than IFN-γ in the pathogenesis of chronic alopecia areata, with increasing severity linked to Th17 lymphocytes and cytotoxic T lymphocyte infiltration.
research IL-15 in alopecia areata: the immune tolerance mechanistic insights and translational perspectives
This study suggests that low-dose IL-2 and IL-15 may help restore immune tolerance in alopecia areata by maintaining Treg cell function, presenting a potential new treatment strategy.
research Hair follicles as immune targets: unraveling cellular players, cytokine crosstalk, and precision pathways for future therapy of alopecia areata
This review highlights that alopecia areata is characterized by three immune endotypes, and while JAK inhibitors offer temporary control, upcoming multi-omics diagnostics and immune reprogramming strategies may achieve longer-lasting remission, according to this analysis.
research Extensive alopecia areata is reversed by IL-12/IL-23p40 cytokine antagonism
In this study, three patients with extensive alopecia areata showed varying degrees of hair regrowth after 20 weeks of treatment with ustekinumab, a cytokine-targeting therapy.
research Paradoxical Alopecia Areata Induced by IL‐17 and IL‐23 Inhibitors: A Systematic Review
This review synthesizes cases of biopsy-confirmed alopecia areata occurring in patients using IL-17 or IL-23 inhibitors, suggesting the need for increased awareness and further investigation into this rare adverse event.
research 033 IL-15 is an unexpected guardian of hair follicle immune privilege and promotes human hair growth ex vivo
This study suggests that rather than inhibiting IL-15, selectively stimulating IL-15Ra-mediated signaling could be beneficial for managing alopecia areata and possibly other inflammatory hair loss conditions, as IL-15 promoted hair growth and maintained immune privilege in human hair follicles.