TLDR Intralesional steroids can help regrow hair in some alopecia areata patients but have side effects.
Intralesional corticosteroids (ILCs), particularly triamcinolone acetonide, were commonly used for treating alopecia areata (AA), especially in cases with less than 50% scalp involvement. The treatment aimed to suppress the immune attack on hair follicles, showing variable efficacy depending on patient characteristics. Studies indicated hair regrowth in a significant proportion of patients, though no randomized controlled trials were available. Adverse effects included pain, skin atrophy, and potential systemic absorption issues. Treatment was recommended to be discontinued if no improvement was observed after six months. Despite limitations, ILCs remained a preferred treatment for patchy, stable AA.
60 citations,
October 2009 in “PubMed” Intralesional steroid injections are safe and effective for treating severe alopecia areata.
71 citations,
March 2009 in “Seminars in cutaneous medicine and surgery” Alopecia areata can cause unpredictable hair loss, and treatments like corticosteroids and minoxidil may help but have varying side effects.
164 citations,
April 2008 in “Cochrane library” Current treatments for alopecia show no significant long-term benefits.
34 citations,
March 2007 in “Biochemical and Biophysical Research Communications” Thioredoxin reductase 1 does not affect glucocorticoid receptor activity in hair follicle cells.
49 citations,
April 2000 in “Journal of The American Academy of Dermatology” Despite progress in treatment, the exact cause of Alopecia areata is still unknown.
April 2019 in “International journal of research in dermatology” A child with rough nails also had hair loss and allergies.
37 citations,
October 2017 in “Clinical and Experimental Dermatology” Oral tofacitinib shows promise in treating atopic dermatitis and alopecia areata, but only slight improvement in vitiligo.
18 citations,
January 2010 in “Dermatology Research and Practice” DPCP treatment for alopecia areata can sometimes cause vitiligo.