P63 Targeted Deletion Under the FOXN1 Promoter Disrupts Pre- and Post-Natal Thymus Development, Function, and Maintenance, and Induces Severe Hair Loss

    January 2022 in “ PloS one ”
    Heather E. Stefanski, Yan Xing, Jemma Nicholls … Bruce R. Blazar
    Studysummary This study found that lineage-restricted loss of p63 in murine thymic epithelial cells resulted in severe thymic hypoplasia and absence of hair follicles, indicating p63's critical role in thymic and hair follicle development.
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    Research cited in this study 4

    1. Identification of an Intronic Regulatory Element Necessary for Tissue-Specific Expression of Foxn1 in Thymic Epithelial Cells ˜The œjournal of immunology/˜The œJournal of immunology · 2019
    2. FOXN1 Deficiency: From the Discovery to Novel Therapeutic Approaches Journal of clinical immunology · 2017
    3. Mutations In AEC Syndrome Skin Reveal A Role For p63 In Basement Membrane Adhesion, Skin Barrier Integrity And Hair Follicle Biology British Journal of Dermatology · 2012
    4. More Than One Way to Skin Genes & Development · 2008