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GlossaryThymic Epithelial Cells

specialized cells in thymus aiding T-cell development

Thymic Epithelial Cells (TECs) are specialized cells found in the thymus, an organ located in the chest. These cells play a crucial role in the development and maturation of T-cells, which are essential for the immune system to function properly. TECs create a supportive environment for T-cells to learn how to distinguish between the body's own cells and foreign invaders, helping to prevent autoimmune diseases.

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research Microenvironmental Reprogramming of Thymic Epithelial Cells to Skin Multipotent Stem Cells

116 citations, August 2010 in “Nature”

Scientists turned rat thymus cells into stem cells that can help repair skin and hair.

research Identification of an Intronic Regulatory Element Necessary for Tissue-Specific Expression of Foxn1 in Thymic Epithelial Cells

17 citations, June 2019 in “The journal of immunology/The Journal of immunology”

A specific DNA region is crucial for Foxn1 gene expression in thymus cells but not in hair follicles.

research FOXN1: A Master Regulator Gene of Thymic Epithelial Development Program

69 citations, January 2013 in “Frontiers in Immunology”

The FOXN1 gene is crucial for developing immune cells and preventing immune disorders.

research Lineage Potential, Plasticity, and Environmental Reprogramming of Epithelial Stem/Progenitor Cells

4 citations, May 2014 in “Biochemical Society Transactions”

Environmental cues can change the fate and function of epithelial cells, with potential for cell therapy.

research DKK1 Mediated Inhibition of Wnt Signaling in Postnatal Mice Leads to Loss of TEC Progenitors and Thymic Degeneration

56 citations, February 2010 in “PLOS ONE”

Blocking Wnt signaling in young mice causes thymus shrinkage and cell loss, but recovery is possible when the block is removed.

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