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    Glossary Thymic Epithelial Cells

    specialized cells in thymus aiding T-cell development

    Thymic Epithelial Cells (TECs) are specialized cells found in the thymus, an organ located in the chest. These cells play a crucial role in the development and maturation of T-cells, which are essential for the immune system to function properly. TECs create a supportive environment for T-cells to learn how to distinguish between the body's own cells and foreign invaders, helping to prevent autoimmune diseases.

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    Research 30 of 634

    1. Microenvironmental reprogramming of thymic epithelial cells to skin multipotent stem cells Nature · 2010 · 116 citations
    2. Identification of an Intronic Regulatory Element Necessary for Tissue-Specific Expression of <i>Foxn1</i> in Thymic Epithelial Cells 2019 · 17 citations
    3. Thymic epithelial cells : relatives of multipotent stem cells of the skin Infoscience (Ecole Polytechnique Fédérale de Lausanne) · 2008
    4. Molecular and Functional Characterization of Clonogenic Human Thymic Epithelial Cells Infoscience (Ecole Polytechnique Fédérale de Lausanne) · 2012
    5. FOXN1: A Master Regulator Gene of Thymic Epithelial Development Program Frontiers in Immunology · 2013 · 69 citations
    6. Morphogenesis and maintenance of the 3D thymic medulla and prevention of nude skin phenotype require FoxN1 in pre- and post-natal K14 epithelium Journal of molecular medicine · 2010 · 21 citations
    7. Lineage potential, plasticity and environmental reprogramming of epithelial stem/progenitor cells Biochemical Society Transactions · 2014 · 4 citations
    8. (Neuro-)endocrinology of epithelial hair follicle stem cells Molecular and Cellular Endocrinology · 2008 · 42 citations
    9. Patterns of desmocollin synthesis in human epithelia: immunolocalization of desmocollins 1 and 3 in special epithelia and in cultured cells. PubMed · 1996 · 96 citations
    10. Patterns of expression of trichocytic and epithelial cytokeratins in mammalian tissues II. Concomitant and mutually exclusive synthesis of trichocytic and epithelial cytokeratins in diverse human and bovine tissues (hair follicle, nail bed and matrix, lingual papilla, thymic reticulum) Differentiation · 1988 · 187 citations
    11. DKK1 Mediated Inhibition of Wnt Signaling in Postnatal Mice Leads to Loss of TEC Progenitors and Thymic Degeneration PLOS ONE · 2010 · 56 citations
    12. Heterozygous FOXN1 Variants Cause Low TRECs and Severe T Cell Lymphopenia, Revealing a Crucial Role of FOXN1 in Supporting Early Thymopoiesis American journal of human genetics · 2019 · 53 citations
    13. Angelica sinensis promotes cortical regeneration of the thymus in mice with acute thymic involution induced by short-term rapamycin treatment Journal of Zhejiang University (Medical Sciences) · 2026
    14. Homeostatic Control of Sebaceous Glands by Innate Lymphoid Cells Regulates Commensal Bacteria Equilibrium Cell · 2019 · 181 citations
    15. FoxN1 in K14 promoter-driven epithelium is required for generation and maintenance of 3D-thymus medulla and preventing nude phenotype in the skin (36.33) 2010
    16. Thymic Mesenchymal Cells Have a Distinct Transcriptomic Profile 2016 · 18 citations
    17. Transcriptional regulation of the thymus master regulator <i>Foxn1</i> Science immunology · 2022 · 6 citations
    18. P63 targeted deletion under the FOXN1 promoter disrupts pre-and post-natal thymus development, function and maintenance as well as induces severe hair loss PloS one · 2022 · 5 citations
    19. Patients with Compound Heterozygous Mutations in Forkhead Box N1 have a Severe Immunodeficiency while Maintaining Normal Skin and Hair Development 2017
    20. Editors' Picks Journal of Investigative Dermatology · 2011
    21. Over-, ectopic-expression of FoxN1 at early life adversely influences lymphopoiesis (HEM3P.280) 2014
    22. Human ClinicalPhenotype Associated with FOXN1 Mutations Advances in experimental medicine and biology · 2009 · 22 citations
    23. RANK as a therapeutic target in cancer ˜The œFEBS journal · 2016 · 50 citations
    24. Unraveling the Link Between Ectodermal Disorders and Primary Immunodeficiencies International reviews of immunology · 2015 · 9 citations
    25. The nude gene and the skin Experimental Dermatology · 2001 · 41 citations
    26. Developing stratified epithelia: lessons from the epidermis and thymus Wiley interdisciplinary reviews. Developmental biology · 2014 · 27 citations
    27. Biological significance of FoxN1 gain-of-function mutations during T and B lymphopoiesis in juvenile mice Cell death and disease · 2014 · 16 citations
    28. Learning from nudity: lessons from the nude phenotype Experimental Dermatology · 2005 · 86 citations
    29. MHC Class I-Like MILL Molecules Are β2-Microglobulin-Associated, GPI-Anchored Glycoproteins That Do Not Require TAP for Cell Surface Expression The Journal of Immunology · 2006 · 16 citations
    30. Human FOXN1-Deficiency Is Associated with αβ Double-Negative and FoxP3+ T-Cell Expansions That Are Distinctly Modulated upon Thymic Transplantation PloS one · 2012 · 32 citations