FOXN1: A Master Regulator Gene of Thymic Epithelial Development Program

January 2013 in “ Frontiers in Immunology ”

Rosa Romano, Loredana Palamaro, Anna Fusco, Giuliana Giardino, Vera Gallo, Luigi Del Vecchio, Claudio Pignata

FOXN1 thymic epithelial cells TEC T cell development thymic architecture autoimmunity Nude/SCID phenotype congenital alopecia thymus transplantation athymic disorders thymic epithelial integrity thymus T cells alopecia

Studysummary This review summarizes existing knowledge on the role of FOXN1 as a key regulator of thymic epithelial cell lineage and function, reporting no new experimental results.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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Human FOXN1 Deficiency Is Associated with Alpha Beta Double-Negative and FoxP3 Positive T-Cell Expansions That Are Distinctly Modulated upon Thymic Transplantation

research Human FOXN1 Deficiency Is Associated with Alpha Beta Double-Negative and FoxP3 Positive T-Cell Expansions That Are Distinctly Modulated upon Thymic Transplantation

32 citations , May 2012 in “PloS one”

This study found that despite the persistence of aberrant double-negative T-cells, functional immune-competence was maintained after thymic transplantation in a patient with a rare FOXN1 mutation.

research First Use of Thymus Transplantation Therapy for FOXN1 Deficiency (Nude/SCID): A Report of 2 Cases

103 citations , January 2011 in “Blood”

This study found that thymus transplantation in infants with FOXN1 deficiency led to T-cell reconstitution and functional immunity, resolving serious infections and cytopenias.

research Learning From Nudity: Lessons From The Nude Phenotype

86 citations , October 2005 in “Experimental Dermatology”

This review explores the role of Foxn1 in mammalian skin biology, discussing its influence on hair follicle function and the potential for further research to enhance understanding of epithelial differentiation.