Morphogenesis and Maintenance of the 3D Thymic Medulla and Prevention of Nude Skin Phenotype Require FoxN1 in Pre- and Post-Natal K14 Epithelium

    November 2010 in “ Journal of molecular medicine ”
    Junkang Guo, Moshiur Rahman, Lili Cheng, Shangmin Zhang, Amy Tvinnereim, Dongming Su
    Image of study
    TLDR FoxN1 gene is essential for proper thymus structure and preventing hair loss.
    The study demonstrated that the FoxN1 gene was crucial for the morphogenesis and maintenance of the 3D thymic medulla and the prevention of a nude skin phenotype. Using a loxP-floxed-FoxN1 mouse model, researchers found that specific deletion of FoxN1 in keratin-14 (K14) promoter-driven thymic epithelial cells (TECs) led to the formation of 2D epithelial cysts and a loss of 3D thymic structure, which increased with age. This deletion also caused a complete hair follicle defect, resulting in a nude skin phenotype. These changes required FoxN1 deletion in both prenatal and postnatal life. The findings highlighted the distinct roles of FoxN1 in the thymus and skin, emphasizing its importance in 3D thymic epithelial morphogenesis and maintenance.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 6 results

      community How does dutasteride regrowth work?

      in Finasteride/Dutasteride  6 upvotes 7 months ago
      A 25-year-old man with hair loss from bleach damage is using oral minoxidil and considering adding Dutasteride for better regrowth and prevention. He seeks advice on Dutasteride's effectiveness and potential benefits over finasteride, and is also curious about RU58841.

      community Massive hair gains! Hope! May this post be a light to you in dark phases when all other lights go out

      in Progress Pictures  193 upvotes 7 months ago
      A 27-year-old man saw significant hair regrowth after starting a regimen in January that included topical minoxidil with finasteride, vitamins D and B12, fish oil, zinc with magnesium, quitting smoking, and intermittent fasting. People commented on the effectiveness of minoxidil in Southern populations and asked about the details and timeline of his treatment.

      community Stop expecting results in 2 months!

      in Treatment  125 upvotes 7 months ago
      People discussing hair loss treatments emphasize the need for patience, as results from using finasteride and minoxidil can take 8-12 months or longer. Some users report early signs of improvement, while others experience continued shedding or slower progress.

      community Fats on your Head to Stop Hair Loss?

      in Research/Science  142 upvotes 10 months ago
      The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

      community Kintor Phase 2 Results released KX-826 (pyrilutamide)

      in Research/Science  451 upvotes 2 years ago
      Kintor Pharmaceutical's Phase 2 results with the drug Pyrilutamide, a potential alternative to 5-ARI drugs like Finasteride and Dutasteride but without the side effects. It could be used in combination with other topical treatments such as Minoxidil. The safety of the drug has been demonstrated in 6 months of use, however there are still questions about long term efficacy and systemic absorption.

    Similar Research

    5 / 647 results