MHC Class I-Like MILL Molecules Are β2-Microglobulin-Associated, GPI-Anchored Glycoproteins That Do Not Require TAP for Cell Surface Expression

    September 2006 in “ The Journal of Immunology ”
    Mizuho Kajikawa, Tomohisa Baba, Utano Tomaru, Yutaka Watanabe, Satoru Koganei, Sachiyo Tsuji-Kawahara, Naoki Matsumoto, Kazuo Yamamoto, Masaaki Miyazawa, Katsumi Maenaka, Akihiro Ishizu, Masanori Kasahara
    TLDR MILL molecules are unique immune proteins in mice that don't need TAP to appear on cell surfaces.
    The study characterized mouse MILL molecules, revealing them as β2-microglobulin-associated, GPI-anchored glycoproteins that did not require TAP for cell surface expression, unlike classical MHC class I molecules. MILL1 and MILL2 were found to be GPI-anchored and associated with β2-microglobulin, suggesting non-peptide presentation functions. MILL1 was expressed in thymic medullary epithelial cells and hair follicles, indicating a potential immunological role, possibly related to immune privilege in hair follicles. The study concluded that MILL molecules are distinct from MICA/B, not stress-inducible, and may serve specialized immune functions in rodents. Further research was suggested to elucidate their biological function.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 35 results

      community To everyone who cant use FIN and doesnt want to use RU

      in Treatment  33 upvotes 3 months ago
      A new hair loss treatment, KX-826, is being discussed as a stronger and safer alternative to RU58841 and finasteride. Opinions are mixed, with some users skeptical about its effectiveness and others considering it as part of their regimen.

      community Chris Bumstead Hair Tansplant at Now Hair Time

      in Transplants  476 upvotes 11 months ago
      Chris Bumstead got a hair transplant at Now Hair Time, and the discussion focuses on why he chose a less reputable clinic despite having the means for a better one, with some suggesting it was for financial gain. The conversation also touches on concerns about the naturalness of the hairline and the potential impact of his steroid use on the transplant's success.

      community blueprint is working so well it seems

      in Chat  541 upvotes 3 months ago
      The conversation discusses a person successfully using a combination of Minoxidil, finasteride, and other treatments for hair loss, resulting in significantly improved hair. Despite some criticism, many admire his dedication to health and anti-aging research.

      community 2years progress (21 years old)

      in Progress Pictures  107 upvotes 3 months ago
      A user shared their two-year progress using 1mg finasteride, topical minoxidil, and occasional microneedling, noting no significant changes but a halt in hair loss progression. They recently started oral minoxidil and are considering a hair transplant.

    Similar Research

    5 / 402 results