Defining the Transcriptional Signature of Esophageal-to-Skin Lineage Conversion

    February 2021 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Maria Teresa Béjar, Paula Jimenez-Gomez, Ilias Moutsopoulos, Bartomeu Colom, Seungmin Han, Fernando J Calero-Nieto, Berthold Göttgens, Irina Mohorianu, Benjamin D. Simons, Maria P. Alcolea
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    TLDR Adult esophageal cells can start to become like skin cells, with a key pathway influencing this change.
    In the study, researchers developed a 3D culture system to investigate how adult esophageal epithelial cells can change their identity when exposed to the stroma of adult skin. They found that these esophageal cells could transition towards a hair follicle identity and architecture, a process that was also replicated in vivo through heterotypic transplantation experiments. Single-cell RNA sequencing and histological analysis showed that most esophageal cells in the process of converting to skin identity remained in an intermediate state characterized by a regenerative profile and a strong hypoxic signature. The inhibition of the HIF1a pathway was identified as a key regulator of this epithelial cell plasticity, suggesting that it plays a central role in driving the cells away from their transitional state and towards complete cell fate conversion.
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