Wounding Induces Dedifferentiation of Epidermal Gata6+ Cells and Acquisition of Stem Cell Properties

    May 2017 in “ Nature cell biology ”
    Giacomo Donati, Emanuel Rognoni, Toru Hiratsuka, Kifayathullah Liakath‐Ali, Esther Hoste, Gozde Kar, Melis Kayikci, Roslin Russell, Kai Kretzschmar, Klaas W. Mulder, Sarah A. Teichmann, Fiona M. Watt
    TLDR Wounded skin cells can revert to stem cells and help heal.
    The study concluded that wounding induced the dedifferentiation of epidermal Gata6+ cells, leading them to acquire stem cell properties, which was significant for regenerative medicine and wound healing. Researchers used mouse models and various genetic and molecular techniques to show that Gata6+ cells, typically found in sebaceous ducts, migrated to the interfollicular epidermis during wound healing, where they dedifferentiated and exhibited long-term self-renewal and multi-lineage differentiation potential. This dedifferentiation was observed up to 124 days post-wounding and suggested that terminally differentiated epidermal cells could revert to a more primitive state, contributing to wound repair.
    Discuss this study in the Community →

    Research cited in this study

    11 / 11 results

    Related Community Posts Join

    6 / 58 results

      community Unofficial Dermapen/Roller Guide

      in Treatment  256 upvotes 6 years ago
      Treatments for hair loss, including microneedling (dermarolling and dermapen) and the use of minoxidil, finasteride, and RU58841. It provides detailed information about cost and usage of the various treatments, as well as potential side effects.

      community Microneedling regime – frequency and depth

      in Microneedling  11 upvotes 1 year ago
      Microneedling frequency and depth, with suggested protocols involving 0.3mm every day before applying topical treatments like Minoxidil or Finasteride, and 0.5-1.5mm once or twice a month for wounding.

      community Anti Fibrosis and Calcification regimen?

      in Question  10 upvotes 6 years ago
      The user experienced no improvement in hair loss with finasteride and minoxidil but had side effects. They plan to add wounding, scalp massage, vitamin K, and taurine supplements to their regimen and seek feedback on these additions.

      community Roughly 1.5 years progress. Dut, Fin, Minox, RU.

      in Progress Pictures  795 upvotes 2 years ago
      A user's progress with treatments for hair loss, including Dutasteride, Finasteride, Minoxidil, and RU. Other members of the conversation provided tips such as using Microneedling and Tretinoin to increase regrowth and wounding areas of the scalp that are thinning in order to fill them in.

      community could Tretinoin alone cause regrowth?

      in Treatment  7 upvotes 1 year ago
      The user has maintained their hairline with finasteride for 5 years and saw no results from minoxidil. They are inquiring if tretinoin alone can cause hair regrowth.

    Similar Research

    5 / 1000+ results