Wounding Induces Dedifferentiation of Epidermal Gata6+ Cells and Acquisition of Stem Cell Properties

May 2017 in “ Nature cell biology ”

Giacomo Donati, Emanuel Rognoni, Toru Hiratsuka, Kifayathullah Liakath‐Ali, Esther Hoste, Gozde Kar, Melis Kayikci, Roslin Russell, Kai Kretzschmar, Klaas W. Mulder, Sarah A. Teichmann, Fiona M. Watt

wounding dedifferentiation epidermal cells Gata6+ cells stem cell properties regenerative medicine wound healing sebaceous ducts interfollicular epidermis self-renewal multi-lineage differentiation terminally differentiated cells wound repair stem cells skin cells healing skin repair

TLDR Wounded skin cells can revert to stem cells and help heal.

The study concluded that wounding induced the dedifferentiation of epidermal Gata6+ cells, leading them to acquire stem cell properties, which was significant for regenerative medicine and wound healing. Researchers used mouse models and various genetic and molecular techniques to show that Gata6+ cells, typically found in sebaceous ducts, migrated to the interfollicular epidermis during wound healing, where they dedifferentiated and exhibited long-term self-renewal and multi-lineage differentiation potential. This dedifferentiation was observed up to 124 days post-wounding and suggested that terminally differentiated epidermal cells could revert to a more primitive state, contributing to wound repair.

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