Transcriptional Regulation of the Thymus Master Regulator Foxn1

    August 2022 in “ Science immunology ”
    Noam Kadouri, Tal Givony, Shir Nevo, Joschka Hey, Shifra Ben‐Dor, Golda Damari, Bareket Dassa, Jan Dobeš, Dieter Weichenhan, Marion Bähr, Michelle T. Paulsen, Rebecca Haffner‐Krausz, Marcus Mall, Christoph Plass, Yael Goldfarb, Jakub Abramson
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    TLDR Foxn1 gene regulation is crucial for thymus development but not for hair growth.
    The study by Kadouri et al. investigates the transcriptional regulation of the Foxn1 gene, crucial for thymic epithelial cells (TECs) and hair follicle cells (HFCs). Key findings include the identification of critical regulatory regions necessary for Foxn1 expression in TECs but not in HFCs, with a small deletion in the AR3 region significantly reducing thymus size without affecting hair growth. Transcription factors SIX1 and FOXN1 were identified as key regulators of Foxn1 expression in TECs. The study also highlights the role of DNA methylation and histone modifications in regulating Foxn1 expression, providing a deeper understanding of the precise regulatory mechanisms controlling Foxn1 and its role in thymic development.
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