Transcriptional Regulation of the Thymus Master Regulator Foxn1

    August 2022 in “ Science immunology ”
    Noam Kadouri, Tal Givony, Shir Nevo … Jakub Abramson
    Studysummary This study identified key regions and transcription factors, including SIX1 and FOXN1 itself, that regulate Foxn1 expression in thymic epithelial cells and hair follicle cells, offering insights into its transcriptional regulation.
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    Research cited in this study 6

    1. Identification of an Intronic Regulatory Element Necessary for Tissue-Specific Expression of Foxn1 in Thymic Epithelial Cells ˜The œjournal of immunology/˜The œJournal of immunology · 2019
    2. Temporal Layering of Signaling Effectors Drives Chromatin Remodeling During Hair Follicle Stem Cell Lineage Progression Cell stem cell · 2018
    3. Isolating Hair Follicle Stem Cells and Epidermal Keratinocytes from Dorsal Mouse Skin Journal of Visualized Experiments · 2016
    4. Pioneer Factors Govern Super-Enhancer Dynamics in Stem Cell Plasticity and Lineage Choice Nature · 2015
    5. The Nude Mutant Gene Foxn1 Is a HOXC13 Regulatory Target During Hair Follicle and Nail Differentiation ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2010
    6. Whn and mHa3 Are Components of the Genetic Hierarchy Controlling Hair Follicle Differentiation Mechanisms of Development · 1999