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P63 Targeted Deletion Under the FOXN1 Promoter Disrupts Pre- and Post-Natal Thymus Development, Function, and Maintenance, and Induces Severe Hair Loss

research P63 Targeted Deletion Under the FOXN1 Promoter Disrupts Pre- and Post-Natal Thymus Development, Function, and Maintenance, and Induces Severe Hair Loss

5 citations, January 2022 in “PloS one”

Deleting the p63 gene in certain cells causes problems in thymus development and severe hair loss in mice.

research Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin

192 citations, March 2017 in “Cell host & microbe”

Hair follicle development and microbes help regulatory T cells gather in newborn skin.

Human FOXN1 Deficiency Is Associated with Alpha Beta Double-Negative and FoxP3 Positive T-Cell Expansions That Are Distinctly Modulated upon Thymic Transplantation

research Human FOXN1 Deficiency Is Associated with Alpha Beta Double-Negative and FoxP3 Positive T-Cell Expansions That Are Distinctly Modulated upon Thymic Transplantation

32 citations, May 2012 in “PloS one”

Thymic transplantation normalized some T-cells but not others, maintaining immune function.

research Biological Significance of FoxN1 Gain-of-Function Mutations During T and B Lymphopoiesis in Juvenile Mice

16 citations, October 2014 in “Cell death and disease”

FoxN1 overexpression in young mice harms immune cell and skin development.

research Transcriptional Regulation of the Thymus Master Regulator Foxn1

6 citations, August 2022 in “Science immunology”

Foxn1 gene regulation is crucial for thymus development but not for hair growth.

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Community Join

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community 1 year fin 1mg and minox. can see some density reclaimed

in Update 562 upvotes 3 years ago

User shared 1-year progress using finasteride 1mg and minoxidil, regaining hair density. Others praised the improvement and asked about side effects and additional treatments.

community Doctor won’t put me on fin or dut until my wife gives birth. Is this normal?

in Finasteride/Dutasteride 12 upvotes 3 months ago

A doctor advised against using finasteride or dutasteride during pregnancy. The user continues with oral and topical minoxidil, microneedling, tretinoin, Nizoral, and pyrilutamide.