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P63 Targeted Deletion Under the FOXN1 Promoter Disrupts Pre- and Post-Natal Thymus Development, Function, and Maintenance, and Induces Severe Hair Loss

research P63 Targeted Deletion Under the FOXN1 Promoter Disrupts Pre- and Post-Natal Thymus Development, Function, and Maintenance, and Induces Severe Hair Loss

5 citations , January 2022 in “PloS one”

Deleting the p63 gene in certain cells causes problems in thymus development and severe hair loss in mice.

research Keratin

6 citations , October 2016

Understanding how keratin structures in hair are arranged and interact is key for creating methods to extract and purify them.

research HOXC13 Is Involved in the Regulation of Human Hair Keratin Gene Expression

132 citations , February 2002 in “Journal of Biological Chemistry”

HOXC13 is crucial for regulating hair keratin genes in hair follicles.

research P63: A Crucial Player In Epithelial Stemness Regulation

54 citations , October 2023 in “Oncogene”

p63 is essential for controlling epithelial stem cells and tissue health.

research Sex Differences in Reaction to Chronic Unpredictable Stress in the House Mouse (Mus m. musculus) of Wild Origin

October 2025 in “Preprints.org”

Male and female mice handle stress differently.

View more "cortical compartment" in research →

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community 4 years of progress pics (Fin only). Hair feels way less dense and is constantly itchy. 30M.

in Progress Pictures 15 upvotes 2 years ago

User has been on Fin for 6 years and shares 4 years of progress pictures, noticing less dense and itchy hair. Replies suggest visiting a dermatologist, considering Dutasteride and Minoxidil, checking bloodwork, and evaluating lifestyle factors.

community EU Shouldn't Ban Fin & Dut: PFS is NOT REAL.

in Research/Science 10 upvotes 1 year ago

Finasteride and Dutasteride do not cause depression or "Post Finasteride Syndrome," with concerns often linked to the nocebo effect and preexisting mental health issues. The EU is unlikely to ban these drugs, but access may become more restricted due to ongoing debates.

community Does someone like Prince William have such intense balding genetics that not even Dutasteride can save them?

in Chat 113 upvotes 1 year ago

Some men have strong balding genetics that treatments like Dutasteride, Minoxidil, or Finasteride may not fully address. Early intervention is believed to help, but many accept hair loss without treatment.

community Finasteride does deplete important nuero-active steroids

in Research/Science 9 upvotes 2 years ago

Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

community I’ve been on dutesteride and oral minoxidil for two years now and I’ve only lost ground…

in Treatment 42 upvotes 2 years ago

A user on dutasteride and oral minoxidil for two years reports worsening hair loss and is seeking advice. Suggestions include consulting a professional for underlying causes, acknowledging that treatments don't work for everyone, and considering dosage adjustments or additional treatments.