TLDR New treatments for immune disorders caused by FOXN1 deficiency are promising.
The document discusses FOXN1 deficiency, which is crucial for the development and function of the thymus, as well as for the differentiation of keratinocytes and hair follicle cells in the skin. The deficiency leads to a condition characterized by a lack of thymus (athymia), severe T cell immunodeficiency, congenital alopecia (hair loss), and nail dystrophy, mirroring the phenotype of the nude mouse. Recent discoveries in the field have been summarized, and the review highlights promising new therapeutic approaches for treating immune system disorders associated with athymia.
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