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    FOXN1 Deficiency: From the Discovery to Novel Therapeutic Approaches

    September 2017 in “ Journal of clinical immunology ”
    Vera Gallo, Emilia Cirillo, Giuliana Giardino, Claudio Pignata
    Studysummary This review summarizes recent findings on FOXN1's essential role in thymus and skin biology and discusses emerging therapeutic approaches for immune disorders with athymia, but reports no new clinical results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 10

    1. FOXN1 Italian Founder Mutation in Indian Family: Implications in Prenatal Diagnosis Gene · 2017
    2. Unraveling the Link Between Ectodermal Disorders and Primary Immunodeficiencies International reviews of immunology · 2015
    3. Human FOXN1 Deficiency Is Associated with Alpha Beta Double-Negative and FoxP3 Positive T-Cell Expansions That Are Distinctly Modulated upon Thymic Transplantation PloS one · 2012
    4. First Use of Thymus Transplantation Therapy for FOXN1 Deficiency (Nude/SCID): A Report of 2 Cases Blood · 2011
    5. Foxn1 Promotes Keratinocyte Differentiation by Regulating the Activity of Protein Kinase C Differentiation · 2007
    6. The Nude Gene and the Skin Experimental Dermatology · 2001
    7. Several Selective Protein Kinase C Inhibitors Including Procyanidins Promote Hair Growth Skin pharmacology and physiology · 2000
    8. Whn and mHa3 Are Components of the Genetic Hierarchy Controlling Hair Follicle Differentiation Mechanisms of Development · 1999
    9. Interleukin-1β Is Differentially Expressed by Human Dermal Papilla Cells in Response to PKC Activation and Is a Potent Inhibitor of Human Hair Follicle Growth in Organ Culture Journal of interferon & cytokine research · 1997
    10. The Secret Life of the Hair Follicle Trends in genetics · 1992