The Hair Loss Encyclopedia

The Nude Gene and the Skin

October 2001 in “ Experimental Dermatology ”

Thomas Schlake

TLDR The nude gene is important for skin and hair development.

The document reviewed the nude gene, which was identified as encoding a transcriptional activator from the forkhead protein family, primarily expressed in thymic epithelium and specific keratinocyte populations in the epidermis and hair follicles. It focused on the molecular and functional characterization of the nude gene and its role in skin biology, including its first identified target genes. The review also discussed the evolutionary aspects of the nude gene, providing insights into its origin and development in molecular and functional terms.

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Research cited in this study

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research Inhibition of BMP Signaling Affects Growth and Differentiation in the Anagen Hair Follicle

305 citations , December 2000 in “The EMBO Journal”

Inhibiting Bmp signaling disrupts hair growth and differentiation.

research Formation of Regulator/Target Gene Relationships During Evolution

25 citations , October 2000 in “Gene”

Gene regulatory regions evolve faster than protein coding regions, allowing new gene relationships without changing transcription factors.

research Forkhead/Winged-Helix Transcription Factor Whn Regulates Hair Keratin Gene Expression: Molecular Analysis of the Nude Skin Phenotype

75 citations , April 2000 in “Developmental Dynamics”

Whn is essential for hair growth, and its malfunction causes hair loss.

research Genetically Separable Determinants of Hair Keratin Gene Expression

27 citations , January 2000 in “Developmental Dynamics”

Mutations in the Whn gene affect hair keratin gene expression differently.

research Whn and mHa3 Are Components of the Genetic Hierarchy Controlling Hair Follicle Differentiation

79 citations , December 1999 in “Mechanisms of Development”

Whn is crucial for hair growth in certain areas by controlling a specific gene.

Ectopic Expression of the Nude Gene Induces Hyperproliferation and Defects in Differentiation: Implications for the Self-Renewal of Cutaneous Epithelia

research Ectopic Expression of the Nude Gene Induces Hyperproliferation and Defects in Differentiation: Implications for the Self-Renewal of Cutaneous Epithelia

69 citations , August 1999 in “Developmental biology”

The nude gene causes skin cell overgrowth and improper development, leading to hair and urinary issues.

research A Novel Serine Protease Overexpressed in the Hair Follicles of Nude Mice

32 citations , May 1999 in “Biochemical and Biophysical Research Communications”

A new enzyme, BSSP, is found in high amounts in the hair follicles of nude mice.

research Keratinocyte Growth Factor Is an Important Endogenous Mediator of Hair Follicle Growth, Development, and Differentiation. Normalization of the Nu/Nu Follicular Differentiation Defect and Amelioration of Chemotherapy-Induced Alopecia.

219 citations , July 1995 in “PubMed”

Keratinocyte growth factor promotes hair growth and reduces hair loss from chemotherapy.

research The Secret Life of the Hair Follicle

745 citations , February 1992 in “Trends in genetics”

Hair follicles create different cell layers and proteins, controlled by various molecules.

research Differences in Activity of Minoxidil and Cyclosporin A on Hair Growth in Nude and Normal Mice: Comparisons of In Vivo and In Vitro Studies

35 citations , January 1990 in “PubMed”

Cyclosporin A boosts hair growth in nude mice, but minoxidil does not.

research Cyclosporin A Stimulates Hair Growth in Nude Mice

55 citations , June 1987 in “PubMed”

Cyclosporin A significantly increases hair growth in certain areas of mice.