Thymosin Beta 4 and Actin: Binding Modes, Biological Functions and Clinical Applications

    December 2022 in “ Current Protein and Peptide Science ”
    Jian‐Li Gao, Yuyuan Ying, Lin Chen, Nana Tao, Robert D. Hoffman, Dongling Shi, Zhijin Chen
    TLDR Thymosin β4 helps in cell activities, healing, and organ preservation, and treats hair loss and skin injuries.
    Thymosin β4 (Tβ4) is a predominant β-thymosin in human cells, playing a crucial role in cellular activities by regulating G-actin polymerization. It influences processes such as motility, development, and differentiation, and has significant effects on inflammation, tumor metastasis, angiogenesis, wound healing, hair follicle regeneration, nervous system development, and bone and tooth growth. Clinically, Tβ4 is used to preserve organs like the kidney, liver, heart, brain, and intestine, and to treat conditions including hair loss, skin trauma, and cornea repair.
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