Contribution to the Study of the Link Between Annonaceae and Parkinsonism: Identification and Quantification of Acetogenins by Dereplication; Phase I Metabolism and Distribution Approach of Annonacin

    February 2012
    Jessica Le Ven
    TLDR Thymosin β4 helps with healing, inflammation, and organ protection.
    Thymosin β4 (Tβ4) was identified as the most highly expressed β-thymosin in human cells, comprising 70-80% of all Tβs. It functioned as a G-actin isolator, inhibiting G-actin polymerization and affecting the balance of F-actin depolymerization and polymerization, which influenced various physiological activities such as cell motility, development, and differentiation. Tβ4 was noted for its wide-ranging effects, including regulation of inflammation, tumor metastasis, angiogenesis, wound healing, hair follicle regeneration, nervous system development, and bone and tooth growth. It had extensive medicinal applications, aiding in the preservation of organs like the kidney, liver, heart, and brain, and was beneficial for conditions such as hair loss, skin trauma, and cornea repair. The review focused on Tβ4's mechanism of action and its clinical applications.
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