Identification of Bioactive Compounds from Thai Plant Extracts with Hair Growth Promoting Activity on Human Hair Dermal Papilla Cells

January 2013

Ruchy Jain

5 alpha-reductase inhibitors androgenic alopecia human hair dermal papilla cells Avicennia marina 5 alpha-reductase type 1 anti-androgenic activity vascular endothelial growth factor Avicequinone C Avicenol C AGA HHDPCs VEGF

TLDR Thai plant extracts, especially Avicennia marina, can promote hair growth by inhibiting certain enzymes and boosting growth factors.

The study focused on identifying natural 5 alpha-reductase inhibitors from Thai plant extracts to treat androgenic alopecia (AGA). Using human hair dermal papilla cells (HHDPCs) and thin layer chromatography, 41 plant extracts were screened. The methanolic heartwood extract of Avicennia marina (AM) showed significant 5 alpha-reductase type 1 inhibitory activity with an IC50 value of 9.21 μg/ml. The extract also demonstrated anti-androgenic activity by up-regulating vascular endothelial growth factor (VEGF), promoting hair growth. The active compound, Avicequinone C, was identified, but its significant VEGF up-regulation required combination with Avicenol C and another unidentified compound. The study concluded that the anti-androgenic activity of AM was due to a synergistic effect of multiple compounds.

View this study on digiverse.chula.ac.th →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 7 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Fats on your Head to Stop Hair Loss?

in Research/Science 140 upvotes 1 year ago

The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 5 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community COMPLETE OVERVIEW of the Treatment of androgenetic alopecia in men

26 upvotes 10 years ago

Male androgenetic alopecia is commonly treated with topical minoxidil and oral finasteride, both requiring continuous use. Other options include hair restoration surgery, dutasteride, light therapy, and camouflaging agents.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 680 upvotes 5 months ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community Natural Remedies: Polyphenols and Hair Loss

20 upvotes 5 years ago

Natural remedies to treat hair loss, such as polyphenols, apple peel extract, grape seed extract, green tea extract, peppermint oil, pumpkin seed oil, apigenin, Ginkgo biloba, red clover extract, olive leaf extract, Ecklonia Cava and Grateloupia elliptica. In addition, terpenes, carotenoids, and tocopherols were discussed as potential treatments.

Related Research

6 / 6 results

research Possible Cellular Communication with Human Follicle Dermal Papilla Cells via Secretions from Human Hair Follicle Keratinocytes

January 2022 in “Journal of St. Marianna University”

Substances from human hair cells can affect hair loss-related genes, potentially leading to new treatments for baldness.

research A Model System to Analyze the Ability of Human Keratinocytes to Form Hair Follicles

15 citations, April 2014 in “Experimental Dermatology”

Scientists developed a system to study human hair growth using skin cells, which could help understand hair development and improve skin substitutes for medical use.

research Review of Hair Follicle Dermal Cells

321 citations, December 2009 in “Journal of Dermatological Science”

Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.