Induction of Hair Keratins Expression by an Annurca Apple-Based Nutraceutical Formulation in Human Follicular Cells

In a study from December 2019, researchers investigated the effects of an Annurca apple-based dietary supplement (AMS) on hair growth, specifically focusing on its ability to induce the expression of hair keratins in human follicular cells. The study, which is part of preclinical research, confirmed the biocompatibility and antioxidant properties of AMS and demonstrated that it stimulates the production of trichokeratins in primary human models of follicular keratinocytes and dermal papilla cells. This finding suggests that AMS has a biological effect on human follicular cells, which may contribute to its hair-inductive activity. The Annurca apple is noted for its high content of oligomeric procyanidins, a type of natural polyphenol that is believed to have various health benefits. The study highlights that none of the current treatments for hair loss have been shown to stimulate hair keratin production as effectively as AMS.