Cysteine Prevents the Reduction in Keratin Synthesis Induced by Iron Deficiency in Human Keratinocytes

    Maria Concetta Miniaci, Carlo Irace, Antonella Capuozzo … Rita Santamaria
    Studysummary This study found that cysteine supplementation significantly increases keratin expression in human keratinocytes, and counteracts the negative impact of iron deficiency on keratin production by enhancing iron availability for cellular processes.
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    Research cited in this study 10

    1. Commentary: Iron Deficiency and Hair Loss Journal of the American Academy of Dermatology · 2010
    2. Iron Deficiency and Diffuse Nonscarring Scalp Alopecia in Women: More Pieces to the Puzzle Journal of The American Academy of Dermatology · 2010
    3. Ferrous Ferric Chloride Stimulates Skin Cell Function and Hair Growth in Mice Biological & pharmaceutical bulletin · 2009
    4. Oxidative Stress in Aging of Hair International Journal of Trichology · 2009
    5. The Human Keratins: Biology And Pathology Histochemistry and Cell Biology · 2008
    6. Chemoprevention of Smoke-Induced Alopecia in Mice by Oral Administration of L-Cystine and Vitamin B6 Journal of dermatological science · 2007
    7. Structural and Molecular Hair Abnormalities in Trichothiodystrophy ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2006
    8. The Diagnosis and Treatment of Iron Deficiency and Its Potential Relationship to Hair Loss Journal of The American Academy of Dermatology · 2006
    9. Hard and Soft Principles Defining the Structure, Function, and Regulation of Keratin Intermediate Filaments Current Opinion in Cell Biology · 2002
    10. Keratins: Dynamic, Flexible Structural Proteins of Epithelial Cells Current problems in dermatology · 2001

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    2. The Disruption of Sox21-Mediated Hair Shaft Cuticle Differentiation Causes Cyclic Alopecia in Mice Proceedings of the National Academy of Sciences · 2009
    3. Functional Analysis of Keratin Components in the Mouse Hair Follicle Inner Root Sheath British Journal of Dermatology · 2004
    4. Type II Epithelial Keratin 6hf (K6hf) Is Expressed in the Companion Layer, Matrix, and Medulla in Anagen-Stage Hair Follicles Journal of Investigative Dermatology · 2003
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    6. HKAP1.6 And HKAP1.7, Two Novel Human High Sulfur Keratin-Associated Proteins Are Expressed In The Hair Follicle Cortex ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    7. Characterization of a Hair (Wool) Keratin Intermediate Filament Gene Domain Journal of Investigative Dermatology · 1994
    8. Regulation of Keratin Gene Expression in Hair Follicle Differentiation Annals of the New York Academy of Sciences · 1991
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    10. Expression of Keratin K14 in the Epidermis and Hair Follicle: Insights Into Complex Programs of Differentiation The Journal of Cell Biology · 1989