Keratins: Dynamic, Flexible Structural Proteins of Epithelial Cells

May 2001 in “ Current problems in dermatology ”

Peter M. Steinert

keratin keratin intermediate filaments epithelial cells keratin genes acidic type I keratin neutral-basic type II keratin epidermolysis bullosa simplex epidermolytic hyperkeratosis human genome project DNA microarrays KIF keratin filaments keratin mutations

TLDR Keratin proteins in epithelial cells are dynamic and crucial for cell processes and disease understanding.

The document discussed the dynamic nature of keratin intermediate filaments (KIF) in epithelial cells, highlighting their constant motion and role in cellular processes like mitosis and wound healing. It detailed the composition of keratins, noting around 40 keratin genes in the human genome, divided into acidic type I and neutral-basic type II proteins. The study also emphasized the link between keratin gene mutations and various diseases, such as epidermolysis bullosa simplex and epidermolytic hyperkeratosis. Future research prospects were promising, with advancements like the human genome project and DNA microarrays expected to enhance understanding of keratin functions and associated proteins.

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