TLDR Overexpressing Tβ4 in cashmere goats improves hair fiber traits and increases cashmere yield.
The study investigated the use of the piggyBac transposon system to overexpress thymosin beta-4 (Tβ4) in cashmere goats, aiming to enhance hair fiber characteristics. Researchers produced five transgenic goats using somatic cell nuclear transfer (SCNT) and found that these goats exhibited a higher secondary to primary hair follicle (S/P) ratio compared to wild type goats, indicating an increased number of secondary hair follicles (SHF). The findings suggested that Tβ4-overexpression could be a viable method to increase cashmere yield by improving hair fiber traits such as length and diameter.
34 citations,
December 2009 in “The International Journal of Developmental Biology” Too much thymosin beta4 causes weird teeth and more hair growth in mice.
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2 citations,
February 2022 in “Genomics” Researchers discovered new cell types in goat hair follicles that could help understand hair regrowth and human hair loss.
[object Object] 8 citations,
July 2020 in “BMC genomics” The research found genes that change during cashmere goat hair growth and could help determine the best time to harvest cashmere.
14 citations,
January 2015 in “Genetics and molecular research” The transition from growth to regression in Cashmere goat hair follicles involves changes in expression of genes related to keratin and cell differentiation.
61 citations,
April 2013 in “PloS one” The study found key genes and pathways involved in cashmere goat hair growth stages.
22 citations,
July 2012 in “Journal of integrative agriculture/Journal of Integrative Agriculture” Hoxc13 is linked to seasonal hair growth in Cashmere goats and is affected by melatonin.
