Tβ4-Overexpression Based on the PiggyBac Transposon System in Cashmere Goats Alters Hair Fiber Characteristics

    November 2016 in “ Transgenic research ”
    Bingbo Shi, Qiang Ding, Xiaolin He, Haijing Zhu, Yaxiao Niu, Bei Cai, Jiao Cai, Anming Lei, Danju Kang, Hailong Yan, Baohua Ma, Xiaolong Wang, Qu Liu, Yulin Chen
    TLDR Overexpressing Tβ4 in cashmere goats improves hair fiber traits and increases cashmere yield.
    The study investigated the use of the piggyBac transposon system to overexpress thymosin beta-4 (Tβ4) in cashmere goats, aiming to enhance hair fiber characteristics. Researchers produced five transgenic goats using somatic cell nuclear transfer (SCNT) and found that these goats exhibited a higher secondary to primary hair follicle (S/P) ratio compared to wild type goats, indicating an increased number of secondary hair follicles (SHF). The findings suggested that Tβ4-overexpression could be a viable method to increase cashmere yield by improving hair fiber traits such as length and diameter.
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