Lentivirus-Mediated Expression of VEGF165 in Rat Hair Follicle Stem Cells

    April 2015 in “ MOJ Cell Science & Report ”
    Renfu Quan
    Studysummary This study found that rat hair follicle stem cells can be effectively transfected with VEGF 165 using lentivirus vectors, suggesting their potential use in developing tissue-engineered skin with improved vascularization. Our plain-language summary of this paper — not a Tressless recommendation.
    The study investigated the use of rat hair follicle stem cells (rHFSCs) transfected with VEGF165 via lentivirus vectors to enhance vascularization in tissue-engineered skin. The rHFSCs were isolated from 1-week-old Sprague-Dawley rats and achieved a high transfection rate of 85.8±1.9%, expressing significant levels of VEGF165 mRNA and protein. This indicated that rHFSCs could be a promising cell source for developing tissue-engineered hair follicles, vessels, and skin, addressing the challenge of poor vascularization in tissue-engineered skin.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results