Experimental Study on Vascular Endothelial Growth Factor 165 Gene-Modified Rat Hair Follicle Stem Cells Mediated by Lentiviral Vector

February 2014 in “ PubMed ”

Xuan Zheng, Shichao Xu, Renfu Quan

vascular endothelial growth factor 165 VEGF165 hair follicle stem cells rHFSCs lentiviral vector collagen type IV tissue engineering artificial hair follicles hair stem cells lentivirus collagen IV

TLDR Modified rat hair follicle stem cells can help create artificial hair follicles, blood vessels, and skin.

The study demonstrated that rat hair follicle stem cells (rHFSCs) with high purity and strong proliferation ability could be obtained using a combination of microscopy, tissue cultivation, and rapid cell adhesion on collagen type IV. Additionally, these rHFSCs were successfully modified to express high levels of vascular endothelial growth factor 165 (VEGF165) through lentiviral transfection. This approach offered promising seeding cells for tissue engineering applications, including the construction of artificial hair follicles, blood vessels, and skin.

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