Identification of Long Noncoding RNAs in Mouse Hair Follicle Stem Cells Using Computational Methods

    July 2020 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    N. Paidimukkala, Rui Kuang, Rebecca J. Morris
    TLDR Scientists found new and known long non-coding RNAs in mouse hair follicle stem cells that may be important for stem cell function and could be targets for cancer treatment.
    The study utilized Illumina paired-end sequencing to profile gene expression in mouse hair follicle stem cells, focusing on long non-coding RNAs (lncRNAs). Quality control and data processing identified 2776 mRNAs and 829 lncRNAs with significant differential expression between stem and non-stem cells. Known keratinocyte stem cell genes and both known and novel lncRNAs were identified, including an antisense lncRNA near differentially expressed histone genes. Functional analysis involved genomic location, co-expression, and GO terms. The findings suggest that lncRNAs play significant roles in hair follicle stem cells and cancer, providing a dataset for potential biomarkers and treatment targets in both mice and humans.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community What ever happened to pyrilutamide?

      in Technology  47 upvotes 1 year ago
      Pyrilutamide, a potentially effective hair loss treatment; other topical treatments like RU58841 and CB-03-01 that may have fewer side effects than Pyrilutamide; and the Phase 3 clinical trials of Pyrilutamide, which is likely to be approved by the FDA soon.

      community New Treatments, and a Huge Group Buy with Lots of Research

      in Research/Science  109 upvotes 1 year ago
      A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

      community Do hair follicles dies or are dormant ?

      in Finasteride/Dutasteride  92 upvotes 4 weeks ago
      Hair follicles can be dormant and potentially revived with treatments like finasteride and minoxidil, but irreversible loss occurs if certain structures are destroyed. Early intervention is more effective, and additional methods like microneedling may help.

    Related Research

    5 / 5 results