Identification of Long Noncoding RNAs in Mouse Hair Follicle Stem Cells Using Computational Methods

    July 2020 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    N. Paidimukkala, Rui Kuang, Rebecca J. Morris
    TLDR Scientists found new and known long non-coding RNAs in mouse hair follicle stem cells that may be important for stem cell function and could be targets for cancer treatment.
    The study utilized Illumina paired-end sequencing to profile gene expression in mouse hair follicle stem cells, focusing on long non-coding RNAs (lncRNAs). Quality control and data processing identified 2776 mRNAs and 829 lncRNAs with significant differential expression between stem and non-stem cells. Known keratinocyte stem cell genes and both known and novel lncRNAs were identified, including an antisense lncRNA near differentially expressed histone genes. Functional analysis involved genomic location, co-expression, and GO terms. The findings suggest that lncRNAs play significant roles in hair follicle stem cells and cancer, providing a dataset for potential biomarkers and treatment targets in both mice and humans.
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