Two Mechanisms Regulate Keratin K15 Expression in Keratinocytes: Role of PKC/AP-1 and FOXM1 Mediated Signaling

    June 2012 in “ PloS one ”
    Amrita Bose, Muy-Teck Teh, Iain Hutchison, Hong Wan, Irene M. Leigh, Ahmad Waseem
    Studysummary This study suggests that Keratin 15 expression in stratified epithelia may be regulated by two distinct mechanisms involving PKC/AP-1 pathway for differentiation and FOXM1 for basal cells, challenging its reliability as a sole stem cell marker. Our plain-language summary of this paper — not a Tressless recommendation.
    The study investigated the regulation of keratin K15 expression in keratinocytes, identifying two primary mechanisms: PKC/AP-1 and FOXM1 mediated signaling pathways. PKC/AP-1 signaling was crucial for K15 upregulation during terminal differentiation, particularly under high cell density and phorbol ester treatment, and involved PKCδ and AP-1 activation. FOXM1 mediated basal-specific K15 expression, confirmed by its binding to the K15 promoter. These findings underscored the complexity of K15 regulation and suggested caution in using K15 as a stem cell marker due to its context-dependent expression.
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