Two Mechanisms Regulate Keratin K15 Expression in Keratinocytes: Role of PKC/AP-1 and FOXM1 Mediated Signaling

    June 2012 in “ PloS one ”
    Amrita Bose, Muy-Teck Teh, Iain Hutchison, Hong Wan, Irene M. Leigh, Ahmad Waseem
    TLDR Keratin 15 expression in skin cells is regulated by two mechanisms involving PKC/AP-1 and FOXM1.
    The study investigated the regulation of keratin K15 expression in keratinocytes, identifying two primary mechanisms: PKC/AP-1 and FOXM1 mediated signaling pathways. PKC/AP-1 signaling was crucial for K15 upregulation during terminal differentiation, particularly under high cell density and phorbol ester treatment, and involved PKCδ and AP-1 activation. FOXM1 mediated basal-specific K15 expression, confirmed by its binding to the K15 promoter. These findings underscored the complexity of K15 regulation and suggested caution in using K15 as a stem cell marker due to its context-dependent expression.
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