The Effects of Negative Pressure Therapy on Hair Growth of Mouse Models

    April 2024 in “ Tissue engineering. Part A
    Chun‐Yu Cheng, Ming‐Huei Cheng, Chan‐Shan Yang, Cheng-Han Wang, Joshua Lim, Wei Huang, Cheng-Wei Lin
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    TLDR Negative pressure therapy increases hair growth in mice.
    This study investigated the effects of negative pressure therapy (NPT) on hair growth in nude mice using a custom external tissue expansion device. Mice were treated with 15 and 30 min of continuous negative pressure at 10 mmHg, repeated 5 and 10 times every other day. Results showed significantly higher hair follicle density and angiogenesis in the suction areas, with the highest density observed in mice treated for 15 min over 10 sessions. Immunofluorescence staining confirmed increased expression of hair growth markers. The study concludes that NPT promotes hair follicle growth and angiogenesis through SOX-9- and LHX-2-mediated follicular regeneration and β-catenin-mediated hair follicle morphogenesis, suggesting potential innovative treatments for hair loss.
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