TLDR Recent findings suggest that genetic factors, immune system issues, and skin cell defects might contribute to the development of hidradenitis suppurativa.
The document discusses recent advances in understanding the molecular pathogenesis of hidradenitis suppurativa (HS), emphasizing dysregulated keratins and extracellular matrix (ECM) signaling. Key points include the role of elevated antimicrobial peptide LL-37, Th1/Th17 immune response, and biomarkers like S100A8/A9 and soluble interleukin 2 receptor. It also examines hair follicle stem cell replication stress, IFI16/STING-dependent inflammation, and the contributions of neutrophil extracellular traps, B cells, and type I interferons to immune dysregulation in HS. These insights are essential for developing targeted therapeutic interventions.
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January 2021 in “Experimental dermatology” Acne inversa is an epithelial-driven disease where inflammation is caused by cyst rupture, and treatments should focus on preventing tendril growth for better results.
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