Advances in Molecular Pathogenesis of Hidradenitis Suppurativa: Dysregulated Keratins and ECM Signaling

    February 2022 in “ Seminars in cell & developmental biology ”
    Mahendra Kashyap, Jasim Khan, Rajesh Sinha … Mohammad Athar
    Studysummary This review discusses the complexities of hidradenitis suppurativa pathogenesis, highlighting issues with Notch signaling, immune dysregulation, and the role of keratinocytes and ECM, but reports no new clinical results.
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    Research cited in this study 11

    1. Histologic Progression of Acne Inversa/Hidradenitis Suppurativa: Implications for Future Investigations and Therapeutic Intervention Experimental dermatology · 2021
    2. What Causes Hidradenitis Suppurativa?—15 Years After Experimental Dermatology · 2020
    3. Hair Follicle Stem Cell Replication Stress Drives IFI16/STING-Dependent Inflammation in Hidradenitis Suppurativa Journal of Clinical Investigation · 2020
    4. Matrix Remodelling and MMP Expression/Activation Are Associated with Hidradenitis Suppurativa Skin Inflammation Experimental Dermatology · 2019
    5. Re-Investigating the Basement Membrane Zone of Psoriatic Epidermal Lesions: Is Laminin-511 a New Player in Psoriasis Pathogenesis? Journal of histochemistry and cytochemistry/˜The œjournal of histochemistry and cytochemistry · 2018
    6. Intralesional Triamcinolone for Flares of Hidradenitis Suppurativa: A Case Series Journal of the American Academy of Dermatology · 2016
    7. Impaired Notch-MKP-1 Signalling in Hidradenitis Suppurativa: An Approach to Pathogenesis by Evidence from Translational Biology Experimental dermatology · 2013
    8. Keratins And Disease At A Glance Journal of Cell Science · 2012
    9. The Human Keratins: Biology And Pathology Histochemistry and Cell Biology · 2008
    10. Keratin 17 Modulates Hair Follicle Cycling in a TNFα-Dependent Fashion Genes & Development · 2006
    11. Lack of the Vitamin D Receptor Is Associated with Reduced Epidermal Differentiation and Hair Follicle Growth ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002