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GlossaryS100A8

protein involved in immune response and inflammation

S100A8 is a protein that plays a role in the body's immune response and inflammation. It is part of the S100 family of proteins and is often found in high levels in conditions involving chronic inflammation, such as certain types of alopecia (hair loss) and other inflammatory diseases.

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research S100A8 Induces Cyclophosphamide-Induced Alopecia via NCF2/NOX2-Mediated Ferroptosis

2 citations , February 2025 in “Free Radical Biology and Medicine”

Blocking S100A8 can reduce chemotherapy-induced hair loss.

Exosome-Derived Long Non-Coding RNA AC010789.1 Modified by FTO and hnRNPA2B1 Accelerates Growth of Hair Follicle Stem Cells Against Androgen Alopecia by Activating S100A8/Wnt/β-Catenin Signaling

research Exosome-Derived Long Non-Coding RNA AC010789.1 Modified by FTO and hnRNPA2B1 Accelerates Growth of Hair Follicle Stem Cells Against Androgen Alopecia by Activating S100A8/Wnt/β-Catenin Signaling

January 2025 in “Clinical and Translational Medicine”

A specific RNA can help hair growth in baldness by boosting stem cell activity.

research Selective Expression of Calcium-Binding Proteins S100A8 and S100A9 at Distinct Sites of Hair Follicles

22 citations , September 2001 in “Journal of Investigative Dermatology”

research Laminin 332 Is Indispensable for Homeostatic Epidermal Differentiation Programs

12 citations , May 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

Laminin 332 is essential for normal skin cell behavior and structure.

research Advances in Molecular Pathogenesis of Hidradenitis Suppurativa: Dysregulated Keratins and ECM Signaling

5 citations , February 2022 in “Seminars in cell & developmental biology”

Recent findings suggest that genetic factors, immune system issues, and skin cell defects might contribute to the development of hidradenitis suppurativa.

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