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GlossaryS100A8

protein involved in immune response and inflammation

S100A8 is a protein that plays a role in the body's immune response and inflammation. It is part of the S100 family of proteins and is often found in high levels in conditions involving chronic inflammation, such as certain types of alopecia (hair loss) and other inflammatory diseases.

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research Laminin 332 Is Indispensable for Homeostatic Epidermal Differentiation Programs

12 citations, May 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

Laminin 332 is essential for normal skin cell behavior and structure.

research Advances in Molecular Pathogenesis of Hidradenitis Suppurativa: Dysregulated Keratins and ECM Signaling

5 citations, February 2022 in “Seminars in cell & developmental biology”

Recent findings suggest that genetic factors, immune system issues, and skin cell defects might contribute to the development of hidradenitis suppurativa.

research Upregulation of SERPINB3/B4 and S100A7-9 in Hidradenitis Suppurativa/Acne Inversa

September 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

Certain proteins are significantly increased in the skin of people with hidradenitis suppurativa.

research Significance of the S100A4 Protein in Psoriasis

45 citations, July 2009 in “Journal of Investigative Dermatology”

The S100A4 protein is more common in psoriatic skin and could be a target for treating psoriasis.

Hair Follicle Disruption Facilitates Pathogenesis to UVB-Induced Cutaneous Inflammation and Basal Cell Carcinoma Development in Ptch+/- Mice

research Hair Follicle Disruption Facilitates Pathogenesis to UVB-Induced Cutaneous Inflammation and Basal Cell Carcinoma Development in Ptch+/- Mice

8 citations, March 2014 in “American Journal of Pathology”

Damaged hair follicles make mice more prone to skin inflammation and skin cancer after UV exposure.

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