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GlossaryS100A4

protein involved in cell growth and cancer metastasis

S100A4 is a protein that belongs to the S100 family, which is involved in various cellular processes such as cell growth and motility. It is often associated with cancer progression and metastasis, meaning it can help cancer cells spread to other parts of the body.

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research Invasion and Increased Expression of S100A4 and CYR61 in Mesenchymal Transformed Breast Cancer Cells Is Downregulated by GnRH

21 citations , April 2016 in “International Journal of Oncology”

GnRH treatment can reduce breast cancer cell invasion.

Depletion of S100A4+ Stromal Cells Results in Abnormal Nipple Development and Nursing Failure

research Depletion of S100A4+ Stromal Cells Results in Abnormal Nipple Development and Nursing Failure

January 2026

Lack of certain cells causes abnormal nipple development and nursing failure.

Expression of Calcium-Binding S100 Proteins A4 and A6 in Regions of the Epithelial Sac Associated with the Onset of Hair Follicle Regeneration

research Expression of Calcium-Binding S100 Proteins A4 and A6 in Regions of the Epithelial Sac Associated with the Onset of Hair Follicle Regeneration

72 citations , June 2001 in “Journal of Investigative Dermatology”

S100A4 and S100A6 proteins may activate stem cells for hair follicle regeneration and could be potential targets for hair loss treatments.

research Molecular Regulation of Secondary Hair Follicle Stem Cell by S100a4 in Cashmere Goat

January 2026 in “International Journal of Molecular Sciences”

S100a4 is key for hair growth in cashmere goats.

research Localization of S100A2, S100A4, S100A6, S100A7, and S100P in the Human Hair Follicle

9 citations , July 2014 in “PubMed”

Different S100 proteins have specific roles in various parts of the hair follicle.

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