Hair Follicle Stem Cell Replication Stress Drives IFI16/STING-Dependent Inflammation in Hidradenitis Suppurativa
April 2020
in “
Journal of Clinical Investigation
”
hair follicle stem cells hidradenitis suppurativa replication stress progenitor cells quiescent stem cells replication fork progression ATR/CHK1 pathway cytosolic single-stranded DNA outer root sheath cells DNA damage response cytoplasmic ssDNA micronuclei interferon synthesis IFI16/STING pathway HFSCs HS ssDNA ORSCs
Studysummary This study found that hair follicle stem cells from hidradenitis suppurativa patients showed alterations in cell cycle regulation and DNA replication, potentially linking genetic predisposition to the skin inflammation characteristic of the disease.
Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
Read the full study on jci.org →