Hair Follicle Stem Cell Replication Stress Drives IFI16/STING-Dependent Inflammation in Hidradenitis Suppurativa

    April 2020 in “ Journal of Clinical Investigation ”
    Cindy Orvain, Yea-Lih Lin, Francette Jean-Louis, Hakim Hocini, Barbara Hersant, Yamina Bennasser, Nicolas Ortonne, C. Hotz, Pierre Wolkenstein, Michele Boniotto, Pascaline Tisserand, Cécile Lefebvre, Jean‐Daniel Lelièvre, Monsef Benkirane, Philippe Pasero, Yves Lévy, Sophie Hüe
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    TLDR Stress in hair follicle stem cells causes inflammation in a chronic skin condition through a specific immune response pathway.
    The 2020 study "Hair follicle stem cell replication stress drives IFI16/STING-dependent inflammation in hidradenitis suppurativa" investigated the role of hair follicle stem cells (HFSCs) in hidradenitis suppurativa (HS), a chronic skin condition. The research involved a varying number of participants, with a maximum of 28 HS patients and 15 healthy donors. The researchers found that HS patients had an increased number of proliferating progenitor cells and a loss of quiescent stem cells, which was associated with spontaneous replication stress. This stress led to alterations in replication fork progression, activation of the ATR/CHK1 pathway, and accumulation of cytosolic single-stranded DNA (ssDNA). These alterations were specific to HS-outer root sheath cells (ORSCs), suggesting a cell-intrinsic control of replication stress and DNA damage response in skin. The study also found that these cells accumulated cytoplasmic ssDNA and micronuclei, inducing interferon synthesis through the IFI16/STING pathway. The results suggest that the lack of quiescent stem cells is due to increased stem cell differentiation and not to destruction of HFSCs.
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