Hair Follicle Stem Cell Replication Stress Drives IFI16/STING-Dependent Inflammation in Hidradenitis Suppurativa

    April 2020 in “ Journal of Clinical Investigation ”
    Cindy Orvain, Yea-Lih Lin, Francette Jean-Louis, Hakim Hocini, Barbara Hersant, Yamina Bennasser, Nicolas Ortonne, C. Hotz, Pierre Wolkenstein, Michele Boniotto, Pascaline Tisserand, Cécile Lefebvre, Jean‐Daniel Lelièvre, Monsef Benkirane, Philippe Pasero, Yves Lévy, Sophie Hüe
    Image of study
    TLDR Stress in hair follicle stem cells causes inflammation in a chronic skin condition through a specific immune response pathway.
    The 2020 study "Hair follicle stem cell replication stress drives IFI16/STING-dependent inflammation in hidradenitis suppurativa" investigated the role of hair follicle stem cells (HFSCs) in hidradenitis suppurativa (HS), a chronic skin condition. The research involved a varying number of participants, with a maximum of 28 HS patients and 15 healthy donors. The researchers found that HS patients had an increased number of proliferating progenitor cells and a loss of quiescent stem cells, which was associated with spontaneous replication stress. This stress led to alterations in replication fork progression, activation of the ATR/CHK1 pathway, and accumulation of cytosolic single-stranded DNA (ssDNA). These alterations were specific to HS-outer root sheath cells (ORSCs), suggesting a cell-intrinsic control of replication stress and DNA damage response in skin. The study also found that these cells accumulated cytoplasmic ssDNA and micronuclei, inducing interferon synthesis through the IFI16/STING pathway. The results suggest that the lack of quiescent stem cells is due to increased stem cell differentiation and not to destruction of HFSCs.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 1000+ results

      community Best Microneedle Lengths To Stimulate Stem Cells

      in Microneedling  18 upvotes 1 year ago
      Microneedling with needle lengths of 1.5mm to 2.5mm to stimulate hair follicle stem cells for potential hair growth. Using needles longer than 2.5mm is not recommended due to risk of puncturing veins in the scalp. A dermastamp is suggested over a roller.

      community TDM-105795 phase 2 results are in!

      in Research/Science  28 upvotes 10 months ago
      TDM-105795 showed promising hair growth results, with higher efficacy than placebo and minimal side effects. It activates dormant hair follicle stem cells and may maintain gains without immediate loss, unlike minoxidil.

      community Fun thought experiment about halting hair loss permamently

      in Research/Science  58 upvotes 7 months ago
      A user proposed genetically engineering scalp stem cells to stop androgen receptors from causing hair loss. Others discussed the feasibility, existing research, and potential issues with this approach, including targeting the correct cells and unintended effects.

      community Is there any new drug that looks promising ?

      in Research/Science  25 upvotes 9 months ago
      The conversation discusses GT20029, a drug in Phase II trials that targets androgen receptors with minimal systemic effects, and TDM-105795, a growth stimulant with a different mechanism than minoxidil that may revive papilla stem cells. Both are potential new treatments for hair loss.

    Similar Research

    5 / 1000+ results