TLDR IL-1 family cytokines are crucial for skin defense and healing, but their imbalance can cause skin diseases.
The document reviews the role of the IL-1 family of cytokines in maintaining the skin's immunological barrier, responding to environmental threats, and facilitating wound healing. The IL-1 family, divided into IL-1, IL-18, and IL-36 subfamilies, are expressed in the skin and play a significant role in detecting environmental threats. They are released upon epidermal damage or infection and help orchestrate an immune response, influencing both the innate and adaptive response. They also significantly influence adaptive immunity, both directly and indirectly. However, dysregulation of IL-1 family cytokines can lead to pathological inflammation and contribute to diseases like psoriasis, hidradenitis suppurativa (HS), and AD. The document also discusses the role of IL-1β in the maintenance of chronic, non-healing wounds in diabetic patients, suggesting the inflammasome as a potential therapeutic target.
53 citations,
April 2021 in “Cell Host & Microbe” Skin bacteria, specifically Staphylococcus aureus, help in wound healing and hair growth by using IL-1β signaling. Using antibiotics on skin wounds can slow down this natural healing process.
32 citations,
December 2019 in “The Journal of clinical investigation/The journal of clinical investigation” A protein called IL-36γ causes skin side effects from certain cancer treatments when combined with a common skin bacteria.
222 citations,
August 2009 in “Experimental Dermatology” Stem cells are crucial for wound healing and understanding their role could lead to new treatments, but more research is needed to answer unresolved questions.
1039 citations,
February 2009 in “Nature Reviews Molecular Cell Biology” Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.
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3 citations,
May 2023 in “Frontiers in immunology” Faulty inflammasome activation may lead to autoimmune skin diseases and could be a target for new treatments.
610 citations,
April 2014 in “Nature Reviews Immunology” The document concludes that understanding how the skin's immune system and inflammation work is complex and requires more research to improve treatments for skin diseases.
January 2024 in “Burns and trauma” The skin microbiome helps heal wounds and can be targeted to improve healing.
27 citations,
July 2017 in “European Journal of Dermatology” Certain microRNAs are linked to various skin diseases and could be used to diagnose and treat these conditions.
