IL-36γ Drives Skin Toxicity Induced by EGFR/MEK Inhibition and Commensal Cutibacterium Acnes

    December 2019 in “ ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation ”
    Takashi Satoh, Mark Mellett, Barbara Meier‐Schiesser … Lars E. French
    Studysummary This study found that EGFR and MEK inhibitors may induce acneiform skin toxicities by interacting with the skin bacterium Cutibacterium acnes to increase IL-36γ and IL-8 production in keratinocytes.
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    Research cited in this study 3

    1. Host-Microbiome Interactions and Recent Progress in Understanding the Biology of Acne Vulgaris Microbiome · 2018
    2. Neutralization of IL-8 Prevents Dermatologic Adverse Events Associated with Epidermal Growth Factor Receptor Inhibition PLoS ONE · 2012
    3. Tumor Necrosis Factor-Alpha and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice Cancer Research · 2009